Heitkötter Birthe, Hartmann Wolfgang
Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.
Sektion für Translationale Pathologie, Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.
Pathologe. 2022 May;43(3):174-182. doi: 10.1007/s00292-022-01069-1. Epub 2022 Apr 25.
Osteoclastic giant cells represent a common cellular component of lesions arising in bone. Highlighting this morphological finding, the current WHO classification of bone tumors defines a diagnostic group comprising aneurysmal bone cyst, giant cell tumor of bone and non-ossifying fibroma, which may display morphologic similarities while being distinct with regard to molecular and biological features. Starting with these tumors - putting a focus on lesions arising in bone - this article gives a survey of other (chondrogenic and osteogenic) tumors that frequently contain osteoclastic giant cells, which may, particularly in small biopsies, enter differential diagnosis. Overlapping features with selected giant cell-containing soft tissue tumors, which may be of differential diagnostic relevance in daily routine, are discussed.
破骨细胞样巨细胞是骨病变中常见的细胞成分。世界卫生组织（WHO）当前的骨肿瘤分类突出了这一形态学发现，定义了一个诊断组，包括骨动脉瘤样囊肿、骨巨细胞瘤和非骨化性纤维瘤，这些肿瘤可能在形态上有相似之处，但在分子和生物学特征方面有所不同。本文从这些肿瘤入手——重点关注骨病变——综述了其他（软骨源性和成骨性）经常含有破骨细胞样巨细胞的肿瘤，这些肿瘤在小活检中尤其可能影响鉴别诊断。文中还讨论了与某些含巨细胞的软组织肿瘤的重叠特征，这些特征在日常临床中可能具有鉴别诊断意义。
