Mirsky A F, Tecce J J, Harman N, Oshima H
Psychopharmacologia. 1975;41(1):35-41. doi: 10.1007/BF00421303.
The effects of secobarbital and chlropromazine upon behavior in a continuous, rapidly presented successive (go-no go) discrimination ("attention") task were evaluated in six Macaca mulatta monkeys. Simultaneous monitoring of EEG activity from epidural and subcortical electrodes permitted an evaluation of the nature of altered central nervous system events during erroneous performance (errors of omission) on this task. The computer-assisted analysis of pre-stimulus and post-stimulus EEG frequency activity (baseline crossings) suggests that the best measure of attentive behavior from the pre-stimulus EEG is percentage of beta 2 (25-40 cps) activity. No difference could be observed between drugs or among cerebral placements in this regard. This was determined by comparing measures of EEG frequency, pooled for a given test period, with performance from the same test period. On a trail-by-trail basis. however, the beta 2 measure in the pre-stimulus epoch failed to ditinguish correct responses from errors of omission. Separation between correct responses and errors of omission is possible if comparisons are made between the changes in percentage of beta 2 activity in the pre-stimulus vs. post-stimulus occurs with correct positive trials and the smallest change with correct negative trials. For secobarbital, no difference could be detected between correct and incorrect positive trials. For chlorpromazine, however, there was significantly less change in beta 2 for incorrect positive than for correct positive trials. The results were interpreted in terms of the hypothesis that secobarbital produces errors by depression of the general level of activation whereas chlorpromazine acts by reducing the sensory input which is necessary for correct discrimination performance.
在六只恒河猴身上评估了速可巴比妥和氯丙嗪对连续、快速呈现的相继（去 - 不去）辨别（“注意力”）任务中行为的影响。通过硬膜外和皮层下电极同时监测脑电图活动，能够评估在此任务错误执行（漏做错误）期间中枢神经系统事件改变的性质。对刺激前和刺激后脑电图频率活动（基线交叉）的计算机辅助分析表明，刺激前脑电图中注意力行为的最佳测量指标是β2（25 - 40赫兹）活动的百分比。在这方面，药物之间或脑区放置之间未观察到差异。这是通过将给定测试期内汇总的脑电图频率测量值与同一测试期的表现进行比较来确定的。然而，在逐个试次的基础上，刺激前期的β2测量值无法区分正确反应和漏做错误。如果比较刺激前与刺激后β2活动百分比的变化，正确阳性试次变化最大，正确阴性试次变化最小，那么正确反应和漏做错误之间是可以区分的。对于速可巴比妥，正确和错误阳性试次之间未检测到差异。然而，对于氯丙嗪，错误阳性试次的β2变化明显小于正确阳性试次。这些结果是根据以下假设来解释的：速可巴比妥通过降低总体激活水平产生错误，而氯丙嗪通过减少正确辨别表现所需的感觉输入起作用。
