Otero J B, Mirsky A F
Psychopharmacologia. 1976;46(1):1-9. doi: 10.1007/BF00421542.
Precentral motor cortex neurons were studied under non-drug and drug conditions in three trained monkeys during the performance of a go-no go visual "attention" task. The two drugs studied, secobarbital and chlorpromazine, produced differing patterns of effect on components of the motor sequence involved in reaction time. The following components were considered: The SF interval or the period from stimulus onset to change in neuronal firing; the FR interval, which is the period from change in firing to the beginning of the task response; and MT or movement time, which is the time necessary to complete the response. Secobarbital produced an increase of 80% in SF and a relatively small average change in FR although there was considerable variability in the latter. MT was decreased in most secobarbital experiments. Anatomical factors relating to the FR variability were considered, and the MT decrease was discussed in terms of possible excitatory effects of the drug. Chlorpromazine produced small increases in SF, FR and MT, alternating with periods of complete abolition of performance. The results were discussed in terms of theories of attention deficit following administration of secobarbital and chlorpromazine.
在三只经过训练的猴子执行视觉“注意力”的“是-否”任务时，于非药物和药物条件下对中央前运动皮层神经元进行了研究。所研究的两种药物，速可巴比妥和氯丙嗪，对反应时间所涉及的运动序列成分产生了不同的效应模式。考虑了以下成分：刺激开始到神经元放电变化的间隔时间（SF间隔）；放电变化到任务反应开始的间隔时间（FR间隔）；以及完成反应所需的时间（MT或运动时间）。速可巴比妥使SF增加了80%，FR的平均变化相对较小，尽管后者存在相当大的变异性。在大多数速可巴比妥实验中MT缩短。考虑了与FR变异性相关的解剖学因素，并从药物可能的兴奋作用方面讨论了MT缩短的情况。氯丙嗪使SF、FR和MT有小幅增加，并伴有完全丧失执行能力的时期。根据服用速可巴比妥和氯丙嗪后注意力缺陷的理论对结果进行了讨论。
