Ambrus J L, Mink I B, Courey N G, Niswander K, Moore R H, Ambrus C M, Lillie M A
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):197-200.
During a ten-year period, 348 women were studied for a total of 5877 patient months for changes in hematologic parameters induced by oral contraceptives. Significant increases were observed in Factors I, II, VII, VIII, IX, X and plasminogen. Severe complications developed in four patients. All four had an abnormal blood coagulation profile, suggesting "hypercoagulability" before initiation of therapy. All four patients were of A or AB blood group. It appears from these data that hematologic workups may be useful in women who are about to embark on long-term oral contraceptive therapy.
在十年期间，对348名女性进行了研究，共计5877个患者月，以观察口服避孕药引起的血液学参数变化。观察到因子I、II、VII、VIII、IX、X和纤溶酶原显著增加。四名患者出现了严重并发症。所有四名患者的血液凝固情况均异常，表明在开始治疗前就存在“高凝状态”。所有四名患者均为A或AB血型。从这些数据来看，血液学检查可能对即将开始长期口服避孕药治疗的女性有用。
