Lin W, Zhang J P, Hu Z L, Qian D H
Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai 200433.
Yao Xue Xue Bao. 1997;32(2):93-6.
The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg.L-1 suppressed TNF and IL-6 production from Cal-primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 micrograms.L-1) in a concentration-dependent manner. Treatment with matrine 50 and 100 mg.kg-1 before LPS injection(3.5 mg.kg-1) markedly decreased mouse serum TNF and IL-6. The results suggest that matrine may have protective effect on LPS-induced liver injury.
研究了苦参碱对脂多糖（LPS）诱导的大鼠库普弗细胞肿瘤坏死因子和白细胞介素-6产生的影响。结果表明，在存在脂多糖（LPS，100微克·L-1）的情况下，125、250和500毫克·L-1的苦参碱以浓度依赖的方式抑制了经钙预处理的库普弗细胞中肿瘤坏死因子和白细胞介素-6的产生。在注射LPS（3.5毫克·千克-1）前用50和100毫克·千克-1的苦参碱处理，可显著降低小鼠血清中的肿瘤坏死因子和白细胞介素-6。结果表明，苦参碱可能对LPS诱导的肝损伤具有保护作用。
