Bodek K H
Department of Physical Chemistry Institute of Chemistry, Medical University of Lódź, Poland.
Acta Pol Pharm. 2000 Nov-Dec;57(6):431-40.
The influence of microcrystalline chitosan hydrogel, alone (MCCh) as well as in combination with methylcellulose (MC) or Carbopol (CP), on the release of diclofenac free acid (DA) and its salt (DS) was studied in vitro. Commercial Olfen gel (Mepha Ltd., Switzerland) was applied as a reference preparation. The influence of hydrophilizing agents (1,2-propylene glycol and glycerol) and methycellulose hydrogel on the rheological properties of the vehicle and on the release of drug from modified MCCh hydrogel was studied. The quantity of the released substance was determined by UV-spectroscopy. The results confirmed that release was dependent on the chemical character of the drug and on the type of vehicle. The process of diclofenac release from MCCh hydrogels as well as from Carbopol hydrogels runs in two phases. The first phase is characterised by rapid release whereas in the second phase the release is much slower. The most suitable basis for diclofenac is microcrystalline chitosan hydrogel with addition glycerol, 1,2-propylene glycol, and methylcellulose hydrogel.
体外研究了微晶壳聚糖水凝胶单独使用（MCCh）以及与甲基纤维素（MC）或卡波姆（CP）联合使用对双氯芬酸游离酸（DA）及其盐（DS）释放的影响。将市售的奥尔芬凝胶（瑞士Mepha有限公司）用作参比制剂。研究了亲水剂（1,2 - 丙二醇和甘油）和甲基纤维素水凝胶对载体流变学性质以及对改性微晶壳聚糖水凝胶中药物释放的影响。通过紫外光谱法测定释放物质的量。结果证实，释放取决于药物的化学性质和载体类型。双氯芬酸从微晶壳聚糖水凝胶以及卡波姆水凝胶中的释放过程分为两个阶段。第一阶段的特征是快速释放，而在第二阶段释放则慢得多。双氯芬酸最合适的基质是添加了甘油、1,2 - 丙二醇和甲基纤维素水凝胶的微晶壳聚糖水凝胶。
