Gupta K C, Ravi Kumar M N
Polymer Research Laboratory, Department of Chemistry, University of Roorkee, India.
Biomaterials. 2000 Jun;21(11):1115-9. doi: 10.1016/s0142-9612(99)00263-x.
Beads and microgranules carriers have important potential applications for the administration of therapeutic molecules. A novel approach for the preparation of chitosan beads and microgranules is presented. The present work is an investigation of the in vitro release kinetics of diclofenac sodium (DFS) from chitosan beads and microgranules. The in vitro release profiles of DFS from chitosan beads and microgranules are monitored using Shimadzu 1601 UV-VIS spectrophotometer. Drug release behavior of beads and microgranules has been compared. The release rate of DFS from the beads has been found to be slower in comparison to the microgranules. It may also be noted that the percent and amount of the drug release were much higher in acidic solution than in basic solution, probably due to the swelling properties of the matrix at acidic pH.
珠粒和微粒载体在治疗性分子给药方面具有重要的潜在应用。本文提出了一种制备壳聚糖珠粒和微粒的新方法。本研究旨在考察双氯芬酸钠（DFS）从壳聚糖珠粒和微粒中的体外释放动力学。使用岛津1601紫外可见分光光度计监测DFS从壳聚糖珠粒和微粒中的体外释放曲线。比较了珠粒和微粒的药物释放行为。发现DFS从珠粒中的释放速率比微粒慢。还可以注意到，药物在酸性溶液中的释放百分比和释放量比在碱性溶液中高得多，这可能是由于基质在酸性pH值下的溶胀特性。
