Eggers S D, Salomao D R, Dinapoli R P, Vernino S
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA.
Mayo Clin Proc. 2001 Mar;76(3):327-30. doi: 10.4065/76.3.327.
Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.
默克尔细胞癌是一种罕见的原发性皮肤神经内分泌肿瘤，具有局部侵袭性，且常伴有远处转移。默克尔细胞癌的神经系统并发症较为罕见。我们报告一名69岁男性，他表现为兰伯特-伊顿肌无力综合征，最终被诊断为默克尔细胞癌。随着恶性肿瘤的初始治疗，副肿瘤综合征有所改善。他随后出现了孤立性脑转移，并死于柔脑膜癌病。
