Schott H C, Patterson K S, Eberhart S W
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314, USA.
Vet J. 2001 Mar;161(2):194-204. doi: 10.1053/tvjl.2000.0542.
To determine whether administration of glycerol-containing solutions induces a state of transient hyperhydration in resting euhydrated horses, changes in plasma and urine constituents were measured in four horses for 1 h before and 5 h after nasogastric administration of each of four treatments (Experiment 1). Treatments were applied in a randomized fashion and included: (1) 1.0 g.kg(-)(1)glycerol in 8 L of water (G); (2) 8 L of water (W); (3) 8 L of 0.9% NaCl solution (S); and (4) 1.0 g.kg(-)(1)glycerol in 8 L of 0.9% NaCl solution (GS). In a subsequent study, voluntary water intake was measured hourly for 5 h after nasogastric administration of each treatment (Experiment 2). All treatments produced mild plasma volume expansion ranging from 3.2 to 5.8% in Experiment 1. Administration of glycerol containing solutions increased serum glycerol concentration approximately 100-fold and plasma osmolality (P(osm)) by approximately 10 mOsm/kg and resulted in a tendency towards increased renal water conservation despite increased osmole excretion. In contrast, W treatment decreased plasma and urine osmolality and was accompanied by increased urine production and decreased renal water conservation. Plasma and urine osmolality, as well as renal osmole and water excretion, were unchanged after S administration. In Experiment 2, horses treated with GS voluntarily drank an additional 5.2 +/- 0.9 L of water during the initial hour following nasogastric administration of 8 L of solution. Voluntary water intake with the other treatments was less than 1.0 L for the entire 5 h observation period. Collectively, the results of both experiments suggest that administration of glycerol in saline would produce transient hyperhydration in resting euhydrated horses by enhancing renal water conservation and stimulating voluntary water intake.
为了确定给予含甘油溶液是否会在静息的等渗马匹中诱发短暂的水合过度状态，在对四匹马进行四种处理的鼻胃管给药前1小时和给药后5小时，测量了血浆和尿液成分的变化（实验1）。处理以随机方式进行，包括：（1）8升水中含1.0 g·kg⁻¹甘油（G）；（2）8升水（W）；（3）8升0.9%氯化钠溶液（S）；以及（4）8升0.9%氯化钠溶液中含1.0 g·kg⁻¹甘油（GS）。在随后的一项研究中，在每种处理进行鼻胃管给药后，每小时测量5小时的自愿饮水量（实验2）。在实验1中，所有处理均产生了3.2%至5.8%的轻度血浆容量扩张。给予含甘油溶液使血清甘油浓度增加约100倍，血浆渗透压（P(osm)）增加约10 mOsm/kg，尽管渗透质排泄增加，但仍导致肾脏保水增加的趋势。相比之下，W处理降低了血浆和尿液渗透压，并伴有尿量增加和肾脏保水减少。给予S后，血浆和尿液渗透压以及肾脏渗透质和水排泄均未改变。在实验2中，用GS处理的马匹在鼻胃管给予8升溶液后的最初1小时内自愿多饮了5.2±0.9升水。在整个5小时观察期内，其他处理的自愿饮水量均少于1.0升。总体而言，两个实验的结果表明，在盐水中给予甘油会通过增强肾脏保水和刺激自愿饮水，在静息的等渗马匹中产生短暂的水合过度。
