Riedesel M L, Allen D Y, Peake G T, Al-Qattan K
Department of Biology, University of New Mexico, Albuquerque 87131.
J Appl Physiol (1985). 1987 Dec;63(6):2262-8. doi: 10.1152/jappl.1987.63.6.2262.
Glycerol was tested as an agent to promote hyperhydration of male and female subjects. Series I experiments involved ingesting 0.5, 1.0, or 1.5 g glycerol/kg body wt and within 40 min drinking 0.1% NaCl, 21.4 ml/kg. In series II, 1.0 g glycerol/kg body wt was ingested at time 0, and 25.7 ml/kg of 0.1% NaCl was ingested over a 3.5-h period. Experiments were of 4-h duration and included controls without glycerol as each subject served as his/her control. Blood samples were taken at 40- or 60-min intervals for hemoglobin (Hb), hematocrit (Hct), plasma osmolality, glycerol, and multiple blood chemistry analyses. Urine was collected at 60-min intervals. Glycerol ingestion increased plasma osmolality for 2 h and reduced the total 4-h urine volume. There were no significant changes in Hb or Hct as a result of the glycerol or excess fluid intake. This study demonstrates that glycerol plus excess fluid intake can produce hyperhydration for at least 4 h.
甘油作为一种促进男性和女性受试者过度水化的物质进行了测试。系列I实验包括摄入0.5、1.0或1.5克甘油/千克体重，并在40分钟内饮用0.1%的氯化钠溶液，21.4毫升/千克。在系列II中，在时间0摄入1.0克甘油/千克体重，并在3.5小时内摄入25.7毫升/千克的0.1%氯化钠溶液。实验持续4小时，包括无甘油的对照组，因为每个受试者作为自己的对照。每隔40或60分钟采集血样，进行血红蛋白（Hb）、血细胞比容（Hct）、血浆渗透压、甘油以及多项血液化学分析。每隔60分钟收集尿液。摄入甘油使血浆渗透压升高2小时，并减少了4小时的总尿量。由于摄入甘油或过量液体，Hb或Hct没有显著变化。本研究表明，甘油加过量液体摄入可产生至少4小时的过度水化。
