Ali S H, DeCaprio J A
Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
Semin Cancer Biol. 2001 Feb;11(1):15-23. doi: 10.1006/scbi.2000.0342.
SV40 large T antigen (TAg) is a powerful oncoprotein capable of transforming a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRB) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. Several other features of TAg that appear to contribute to its full transformation potential are yet to be completely understood. Study of TAg therefore continues to provide new insights into the mechanism of cellular transformation.
SV40大T抗原（TAg）是一种强大的癌蛋白，能够转化多种细胞类型。TAg的转化活性很大程度上归因于其对视网膜母细胞瘤（pRB）和p53肿瘤抑制蛋白的干扰。此外，TAg还与其他几种细胞因子结合，包括转录共激活因子p300和CBP，这可能有助于其转化功能。TAg的其他几个似乎有助于其完全转化潜能的特征尚未完全了解。因此，对TAg的研究继续为细胞转化机制提供新的见解。
