Lednicky J A, Butel J S
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Semin Cancer Biol. 2001 Feb;11(1):39-47. doi: 10.1006/scbi.2000.0345.
The regulatory region (RR) of simian virus 40 (SV40) contains enhancer/promoter elements and an origin of DNA replication. Natural SV40 isolates from simian brain or kidney tissues typically have an archetypal RR arrangement with a single 72-basepair enhancer element. A rare simpler, shorter SV40 RR exists that lacks a duplicated sequence in the G/C-rich region and is termed protoarchetypal. Occasionally, SV40 strain variants arise de novo that have complex RRs, which typically contain sequence reiterations, rearrangements, and/or deletions. These variants replicate faster and to higher titers in tissue culture; we speculate that such faster-growing variants were selected when laboratory strains of SV40 were initially recovered. SV40 strains with archetypal RRs have been found in some human brain tumors. The possible implications of these findings and a brief review of the SV40 RR structure are presented.
猴病毒40（SV40）的调控区域（RR）包含增强子/启动子元件和DNA复制起点。从猴脑或肾组织中分离出的天然SV40毒株通常具有典型的RR排列，带有单个72碱基对的增强子元件。存在一种罕见的更简单、更短的SV40 RR，它在富含G/C的区域缺乏重复序列，被称为原原型。偶尔会出现从头产生的具有复杂RR的SV40毒株变体，其通常包含序列重复、重排和/或缺失。这些变体在组织培养中复制更快且滴度更高；我们推测，当最初获得SV40实验室毒株时，选择了这种生长更快的变体。在一些人脑肿瘤中发现了具有典型RR的SV40毒株。本文介绍了这些发现的可能影响以及对SV40 RR结构的简要综述。
