Martini Fernanda, Corallini Alfredo, Balatti Veronica, Sabbioni Silvia, Pancaldi Cecilia, Tognon Mauro
Department of Morphology and Embryology, Section of Cell Biology and Molecular Genetics, School of Medicine, and Center of Biotechnology, University of Ferrara, Via Fossato di Mortara, 64/B, 44100 Ferrara, Italy.
Infect Agent Cancer. 2007 Jul 9;2:13. doi: 10.1186/1750-9378-2-13.
Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SV40-contaminated vaccines.SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors. Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors. As a consequence of the conflicting results, a considerable debate has developed in the scientific community. In the present review we consider the main results obtained by different groups investigating SV40 sequences in human tumors and in blood specimens, the putative role of SV40 in the onset/progression of specific human tumors, and comment on the hypotheses arising from these data.
猴病毒40（SV40）是一种猴病毒，通过在自然感染SV40的猴细胞中生产的受污染疫苗传播给人类群体。最近的分子生物学和流行病学研究表明，SV40可能通过水平感染在人类中进行传染性传播，与早期接种受SV40污染的疫苗无关。在人类中发现SV40踪迹与特定肿瘤类型（如脑肿瘤和骨肿瘤、间皮瘤和淋巴瘤）以及肾脏疾病高度相关，在健康供体的血液样本中出现频率较低。关于SV40通过传染性传播在人类中的循环及其作为可能的病因辅助因素与特定人类肿瘤的关联，文献中出现了相互矛盾的报道。由于结果相互矛盾，科学界展开了相当激烈的辩论。在本综述中，我们考虑了不同研究小组在人类肿瘤和血液样本中研究SV40序列所获得的主要结果、SV40在特定人类肿瘤发生/发展中的假定作用，并对这些数据产生的假设进行评论。
