Hauber H P, Bohuslavizki K H, Lund C H, Fritscher-Ravens A, Meyer A, Pforte A
Department of Internal Medicine, University Hospital Eppendorf, Hamburg, Germany.
Chest. 2001 Mar;119(3):950-4. doi: 10.1378/chest.119.3.950.
Small-cell lung cancer (SCLC) has an unfavorable prognosis, especially when the disease is extensive at presentation. Accurate staging procedures are therefore needed for treatment planning. Positron emission tomography (PET) is a modern noninvasive imaging technique, the value of which for the staging of SCLC was investigated in the present study.
University hospital.
Thirty-one patients with suspected lung cancer were investigated for staging purposes using chest radiography, CT of the thorax and abdomen, abdominal ultrasound, and bone scanning. Twenty-five patients also received PET examinations during the staging procedures. Five of these patients were found to have SCLC, while two patients had mixed lesion types. Further analysis of the latter group was carried out.
PET detected the primary tumor in all patients, and lymph nodes in five patients. All lymph nodes were proved to be malignant by endoscopic ultrasonography-guided fine-needle aspiration. Only one patient had distant metastases, which were detected by both CT and PET.
PET appears be a suitable imaging method in SCLC. A potential role for the technique as a standard staging procedure will need to be tested by investigating a larger number of patients in a prospective study.
小细胞肺癌（SCLC）预后不佳，尤其是疾病初发时已广泛转移的情况。因此，治疗规划需要准确的分期程序。正电子发射断层扫描（PET）是一种现代非侵入性成像技术，本研究对其在SCLC分期中的价值进行了调查。
大学医院。
31例疑似肺癌患者接受了胸部X光、胸部和腹部CT、腹部超声及骨扫描以进行分期检查。25例患者在分期过程中还接受了PET检查。其中5例患者被诊断为SCLC，2例患者为混合病变类型。对后一组患者进行了进一步分析。
PET检测出所有患者的原发性肿瘤以及5例患者的淋巴结。所有淋巴结经内镜超声引导下细针穿刺活检证实为恶性。仅1例患者有远处转移，CT和PET均检测到。
PET似乎是SCLC合适的成像方法。该技术作为标准分期程序的潜在作用需要在前瞻性研究中通过调查更多患者来进行验证。
