Miyamoto Masaki, Morikawa Toshiaki, Kaga Kichizo, Ohtake Setsuyuki, Cho Yasushi, Hirano Satoshi, Kondo Satoshi
Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, N-14 W-7, Kita-ku, Sapporo 060-8648, Japan.
Surg Today. 2006;36(8):671-5. doi: 10.1007/s00595-006-3222-9.
Our aim was to clarify the significance of surgery and the prognostic factors in patients with small cell lung cancer (SCLC).
A retrospective review of 50 patients with limited SCLC who underwent a pulmonary resection and mediastinal nodal dissection during the 10-year period from 1988 to 1997 was undertaken. The TNM classification was applied to all cases of SCLC.
A Cox regression multivariate analysis indicated lymph node metastasis (P = 0.0117) and adjuvant therapy (P = 0.0429) to be independent prognostic factors in SCLC patients. Concerning the patients with lymph node metastasis, the prognosis was related only to the involvement of the subcarinal node (station 7). Although no patient with lymph node involvement in station 7 could be a 2-year survivor, in the case of patients with lymph node involvement except in station 7, 47.1% of them were 2-year survivors and 25.1% were 4-year survivors. Among the patients with lymph node metastasis, a univariate analysis indicated the prognosis to be significantly poorer in patients with station 7 involvement than in those without station 7 involvement (P = 0.0224).
Involvement in the subcarinal node might be a prognostic factor for SCLC.
我们的目的是阐明手术的意义以及小细胞肺癌（SCLC）患者的预后因素。
对1988年至1997年这10年间接受肺切除和纵隔淋巴结清扫术的50例局限性SCLC患者进行回顾性研究。所有SCLC病例均采用TNM分类。
Cox回归多因素分析表明，淋巴结转移（P = 0.0117）和辅助治疗（P = 0.0429）是SCLC患者的独立预后因素。对于有淋巴结转移的患者，预后仅与隆突下淋巴结（7区）受累有关。虽然7区有淋巴结受累的患者无一能存活2年，但在7区以外有淋巴结受累的患者中，47.1%的患者存活了2年，25.1%的患者存活了4年。在有淋巴结转移的患者中，单因素分析表明，7区受累的患者预后明显比未受累的患者差（P = 0.0224）。
隆突下淋巴结受累可能是SCLC的一个预后因素。
