FosB是一种半胱氨酸依赖性磷霉素抗性蛋白，受枯草芽孢杆菌胞外功能σ因子σ（W）的调控。
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
作者信息
Cao M, Bernat B A, Wang Z, Armstrong R N, Helmann J D
机构信息
Department of Microbiology, Cornell University, Ithaca, New York 14853-8101, USA.
出版信息
J Bacteriol. 2001 Apr;183(7):2380-3. doi: 10.1128/JB.183.7.2380-2383.2001.
Abstract
We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma(W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn(2+)-dependent glutathione transferases but with a preference for Mg(2+) and L-cysteine as cofactors.
摘要
我们证明枯草芽孢杆菌fosB（yndN）基因编码一种磷霉素抗性蛋白。fosB的表达需要σ（W），并且fosB和sigW突变体对磷霉素均敏感。FosB是一种金属硫醇转移酶，与依赖锰（2+）的谷胱甘肽转移酶FosA类相关，但更倾向于以镁（2+）和L-半胱氨酸作为辅因子。
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