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2
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FEMS Microbiol Lett. 1990 Mar 15;56(3):267-72. doi: 10.1016/s0378-1097(05)80052-7.
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本文引用的文献

1
Elucidation of a monovalent cation dependence and characterization of the divalent cation binding site of the fosfomycin resistance protein (FosA).磷霉素抗性蛋白（FosA）单价阳离子依赖性的阐明及二价阳离子结合位点的表征
Biochemistry. 1999 Jun 8;38(23):7462-9. doi: 10.1021/bi990391y.
2
Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26.产志贺毒素大肠杆菌O26磷霉素耐药菌株的出现。
Antimicrob Agents Chemother. 1999 Apr;43(4):789-93. doi: 10.1128/AAC.43.4.789.
3
Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W.枯草芽孢杆菌胞外功能σ因子σW的靶启动子鉴定
Mol Microbiol. 1999 Jan;31(1):361-71. doi: 10.1046/j.1365-2958.1999.01180.x.
4
Promoter recognition by Bacillus subtilis sigmaW: autoregulation and partial overlap with the sigmaX regulon.枯草芽孢杆菌σW对启动子的识别：自动调节及与σX调控子的部分重叠
J Bacteriol. 1998 Aug;180(15):3765-70. doi: 10.1128/JB.180.15.3765-3770.1998.
5
The extracytoplasmic function sigma factors: role and regulation.胞质外功能σ因子：作用与调控
Mol Microbiol. 1998 Jun;28(6):1059-66. doi: 10.1046/j.1365-2958.1998.00865.x.
6
Identification of target promoters for the Bacillus subtilis sigma X factor using a consensus-directed search.使用一致性导向搜索鉴定枯草芽孢杆菌σX因子的靶启动子
J Mol Biol. 1998 May 29;279(1):165-73. doi: 10.1006/jmbi.1998.1765.
7
The Bacillus subtilis sigma(X) protein is an extracytoplasmic function sigma factor contributing to survival at high temperature.枯草芽孢杆菌σ(X)蛋白是一种胞外功能σ因子，有助于在高温下存活。
J Bacteriol. 1997 May;179(9):2915-21. doi: 10.1128/jb.179.9.2915-2921.1997.
8
Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases.磷霉素抗性蛋白（FosA）是一种与乙二醛酶I和双加氧酶相关的锰金属谷胱甘肽转移酶。
Biochemistry. 1997 Mar 18;36(11):3050-5. doi: 10.1021/bi963172a.
9
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.UDP-N-乙酰葡糖胺烯醇丙酮酸转移酶的结构，该酶是细菌肽聚糖合成所必需的一种酶，与底物UDP-N-乙酰葡糖胺和药物磷霉素形成复合物。
Structure. 1996 Dec 15;4(12):1465-74. doi: 10.1016/s0969-2126(96)00153-0.
10
Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes.微生物中硫醇的分布：在大多数放线菌中，麦角硫因是主要的硫醇。
J Bacteriol. 1996 Apr;178(7):1990-5. doi: 10.1128/jb.178.7.1990-1995.1996.

FosB是一种半胱氨酸依赖性磷霉素抗性蛋白，受枯草芽孢杆菌胞外功能σ因子σ（W）的调控。

FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.

作者信息

Cao M, Bernat B A, Wang Z, Armstrong R N, Helmann J D

机构信息

Department of Microbiology, Cornell University, Ithaca, New York 14853-8101, USA.

出版信息

J Bacteriol. 2001 Apr;183(7):2380-3. doi: 10.1128/JB.183.7.2380-2383.2001.

DOI:10.1128/JB.183.7.2380-2383.2001
PMID:11244082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC95149/
Abstract

We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma(W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn(2+)-dependent glutathione transferases but with a preference for Mg(2+) and L-cysteine as cofactors.

摘要

我们证明枯草芽孢杆菌fosB（yndN）基因编码一种磷霉素抗性蛋白。fosB的表达需要σ（W），并且fosB和sigW突变体对磷霉素均敏感。FosB是一种金属硫醇转移酶，与依赖锰（2+）的谷胱甘肽转移酶FosA类相关，但更倾向于以镁（2+）和L-半胱氨酸作为辅因子。