Parsad D, Pandhi R, Negi K S, Kumar B
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dermatology. 2001;202(1):35-7. doi: 10.1159/000051582.
To evaluate the role of topical metronidazole gel in the treatment of seborrheic dermatitis.
Forty-four patients with seborrheic dermatitis were enrolled in the study. All topical treatments were stopped for at least 2 weeks before the patients were allocated at random to receive either metronidazole 1% gel or placebo for 8 weeks. The severity score was measured at the initial evaluation, and the patients were followed up at 2-week intervals for 8 weeks. A global evaluation of improvement was done at 8 weeks.
Thirty-eight patients completed the study; 21 patients in the metronidazole group and 17 patients in the placebo group could be evaluated. There was a statistically significant decrease of the mean score even at week 2; the difference became highly significant at 8 weeks (p < 0.001). On the final evaluation at 8 weeks, 14 patients in the metronidazole group showed marked improvement to complete clearance as compared to only 2 patients having moderate improvement in the placebo group (p < 0.001).
The present trial has demonstrated the effectiveness of topical 1% metronidazole gel in seborrheic dermatitis.
评估外用甲硝唑凝胶在治疗脂溢性皮炎中的作用。
44例脂溢性皮炎患者纳入本研究。在患者被随机分配接受1%甲硝唑凝胶或安慰剂治疗8周之前，所有局部治疗均停止至少2周。在初始评估时测量严重程度评分，并对患者进行为期8周的每2周一次的随访。在8周时进行总体改善评估。
38例患者完成研究；甲硝唑组21例患者和安慰剂组17例患者可进行评估。即使在第2周时，平均评分也有统计学意义的下降；在第8周时差异变得非常显著（p < 0.001）。在8周的最终评估中，甲硝唑组14例患者显示明显改善至完全清除，而安慰剂组只有2例患者有中度改善（p < 0.001）。
本试验已证明外用1%甲硝唑凝胶治疗脂溢性皮炎有效。
