Mastropasqua L, Carpineto P, Ciancaglini M, Falconio G, Harris A
Institute of Ophthalmology and Legal Medicine, University 'G. D'Annunzio', Chieti, Italy.
Ophthalmologica. 2001 Mar-Apr;215(2):91-6. doi: 10.1159/000050836.
To evaluate the reproducibility of nerve fiber layer (NFL) thickness measurements by optical coherence tomography (OCT) in individuals with silicone oil-filled eyes.
Eighteen patients who had undergone pars plana vitrectomy and silicone oil tamponade for retinal detachment were enrolled in a prospective, case-controlled clinical study. Each patient underwent OCT measurement of NFL thickness. Five repetitions of a series of scans on five separate occasions within a 0.5-month period were performed. Each eye was scanned at two different nerve head programs [radius (R) = 1.5 and R = 1.73]. The contralateral healthy eye was used as control. For each option (R = 1.5 and R = 1.73) and region (superior, inferior, temporal, nasal and overall mean), variance components and intraclass correlation coefficients (ICCs) were determined using repeated-measures regression. In these models, NFL thickness, as measured by OCT, was considered to have three variance components: intersubject, intervisit (within subject, between dates), and intravisit (within subject, within date). The ICC (intersubject variance/total variance) was used as a measure of reliability.
The contralateral healthy eye provided a higher degree of reproducibility than the silicone oil-filled eye (p = 0.0001). Reproducibility was higher in a given eye on a given visit than from visit to visit. Reproducibility as measured by ICCs was as follows: R = 1.5, 0.54/0.30 (control eyes/silicone oil-filled eyes); R = 1.73, 0.51/0.30.
Reproducibility results for OCT measurement of NFL thickness are different in healthy eyes and silicone oil-filled eyes. NFL thickness measurement is not reliable in silicone oil-filled eyes.
评估光学相干断层扫描（OCT）测量硅油填充眼神经纤维层（NFL）厚度的可重复性。
18例因视网膜脱离接受了玻璃体切割术和硅油填充的患者被纳入一项前瞻性病例对照临床研究。每位患者均接受了NFL厚度的OCT测量。在0.5个月内分5次对每只眼睛进行了一系列扫描的5次重复测量。每只眼睛在两个不同的视盘程序下进行扫描[半径（R）=1.5和R = 1.73]。对侧健康眼作为对照。对于每个选项（R = 1.5和R = 1.73）以及区域（上方、下方、颞侧、鼻侧和总体平均值），使用重复测量回归确定方差成分和组内相关系数（ICC）。在这些模型中，通过OCT测量的NFL厚度被认为有三个方差成分：个体间、访视间（个体内，不同日期之间）和访视内（个体内，同一日期内）。ICC（个体间方差/总方差）被用作可靠性的度量指标。
对侧健康眼比硅油填充眼具有更高的可重复性（p = 0.0001）。在给定的一次就诊中，给定眼睛的可重复性高于不同就诊之间。通过ICC测量的可重复性如下：R = 1.5，0.54/0.30（对照眼/硅油填充眼）；R = 1.73，0.51/0.30。
健康眼和硅油填充眼中OCT测量NFL厚度的可重复性结果不同。硅油填充眼中NFL厚度测量不可靠。
