Hu F B, Chen C, Wang B, Stampfer M J, Xu X
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Int J Obes Relat Metab Disord. 2001 Jan;25(1):121-5. doi: 10.1038/sj.ijo.0801480.
To examine the associations between leptin levels and body mass index (BMI), fat distribution (reflected by waist to hip ratio and skinfold measurements), and blood pressure in a rural Chinese population.
A cross-sectional study of 294 participants who provided blood samples.
Plasma concentrations of leptin, BMI, waist to hip ratio, skinfold thickness, and blood pressure.
The average leptin concentration was 5.2 microg/l (3.1 for men and 7.3 for women). In univariate analyses, leptin levels were significantly correlated with BMI (r=0.47), abdominal skinfold thickness (r=0.53), triceps skinfold thickness (r=0.56), waist circumference (r=0.41), hip circumference (r=0.51), waist to hip ratio (r=0.17), and diastolic blood pressure (r=0.13). In multivariate analyses controlling for age, sex, education, current smoking, and alcohol use, independent associations between leptin levels and BMI, waist to hip ratio, waist circumference, and abdominal skinfold thickness remained. However, the significant association between leptin and blood pressure disappeared after adjusting for BMI, whereas the association between BMI and blood pressure persisted after adjusting for leptin level.
We observed a strong positive relationship between overall adiposity and leptin levels in both men and women in a rural Chinese population. In addition, leptin concentrations were significantly associated with central obesity measured by waist to hip ratio and abdominal skinfold, independent of overall obesity. The observed positive association between leptin and blood pressure was largely explained by BMI. International Journal of Obesity (2001) 25, 121-125
研究中国农村人群中瘦素水平与体重指数（BMI）、脂肪分布（通过腰臀比和皮褶测量反映）及血压之间的关联。
对294名提供血样的参与者进行的横断面研究。
血浆瘦素浓度、BMI、腰臀比、皮褶厚度和血压。
瘦素平均浓度为5.2微克/升（男性为3.1，女性为7.3）。单因素分析中，瘦素水平与BMI（r = 0.47）、腹部皮褶厚度（r = 0.53）、肱三头肌皮褶厚度（r = 0.56）、腰围（r = 0.41）、臀围（r = 0.51）、腰臀比（r = 0.17）和舒张压（r = 0.13）显著相关。多因素分析中，在控制年龄、性别、教育程度、当前吸烟状况和饮酒情况后，瘦素水平与BMI、腰臀比、腰围和腹部皮褶厚度之间仍存在独立关联。然而，调整BMI后，瘦素与血压之间的显著关联消失，而调整瘦素水平后，BMI与血压之间的关联仍然存在。
在中国农村人群中，我们观察到男性和女性的总体肥胖程度与瘦素水平之间存在很强的正相关关系。此外，瘦素浓度与通过腰臀比和腹部皮褶测量的中心性肥胖显著相关，独立于总体肥胖情况。观察到的瘦素与血压之间的正相关关系在很大程度上由BMI解释。《国际肥胖杂志》（2001年）25卷，121 - 125页
