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[三例系统性红斑狼疮合并抗磷脂综合征患者慢性肺血栓栓塞症的肺动脉血栓内膜剥脱术]

[Pulmonary thromboendarterectomy for chronic pulmonary thromboembolism in three patients with systemic lupus erythematosus and antiphospholipid syndrome].

作者信息

Sato N, Kyotani S, Sakamaki F, Nagaya N, Oya H, Nakanishi N

机构信息

Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

出版信息

Nihon Kokyuki Gakkai Zasshi. 2000 Dec;38(12):958-64.

Abstract

Pulmonary hypertension (PH) is a serious and often fatal complication of systemic lupus erythematosus (SLE). Several potential mechanisms have been postulated for narrowing of vessels as a result of pulmonary vasculitis and pulmonary thromboembolism caused by antiphospholipid antibodies. Pulmonary thromboendarterectomy for chronic pulmonary thromboembolism is performed to alleviate pulmonary hypertension. We report three rare cases of SLE with antiphospholipid syndrome in patients who presented with PH secondary to chronic pulmonary thromboembolism. Pulmonary thromboendarterectomy was performed, and all patients remained well without deterioration of PH after surgery. Pulmonary thromboendarterectomy should be considered as an effective method of treatment for this disease.

摘要

肺动脉高压(PH)是系统性红斑狼疮(SLE)的一种严重且往往致命的并发症。对于由抗磷脂抗体引起的肺血管炎和肺血栓栓塞导致的血管狭窄,已经提出了几种潜在机制。针对慢性肺血栓栓塞进行肺血栓内膜剥脱术以缓解肺动脉高压。我们报告了3例罕见的系统性红斑狼疮合并抗磷脂综合征患者,他们因慢性肺血栓栓塞继发肺动脉高压。这些患者接受了肺血栓内膜剥脱术,术后所有患者情况良好,肺动脉高压未恶化。肺血栓内膜剥脱术应被视为治疗该疾病的一种有效方法。

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