Namba M, Chihara E, Ibuki T, Ashida H, Fukushima H, Tanaka Y
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566.
Masui. 2001 Feb;50(2):127-35.
Roxatidine acetate hydrochloride capsule is slowly absorbed from the gastrointestinal tract, and its acid suppressive effect on the stomach is long-lasting compared with other H2-blockers. The reduction of gastric juice in perioperative period is considered advantageous for patients not only because it decreases the risk for aspiration pneumonia but also because it reduces the risk of bronchial spasm induced by gastroesophageal reflux of acidic gastric content. The effects of single oral administration of roxatidine acetate hydrochloride 150 mg at night before the operation on the volume and pH of gastric juice were investigated during anesthesia using two types of anesthetic agents (isoflurane and propofol) in 93 patients of three age groups (group Y: age 20-40, group M: age 41-64, group O: age 65 <). The effect of roxatidine on reduction of gastric juice was found at the time of anesthetic induction and 2 hours after the induction in any age group with either anesthetic agent. The serum concentration of roxatidine at the time of induction was much higher in group O. The value of residual concentration of roxatidine 20 hours after oral intake was estimated from the intraoperative measurements of serum concentration. The results suggest that single administration at night before the operation is sufficient for the oldest group, but an additive dose is recommended for the younger groups.
醋酸罗沙替丁盐酸盐胶囊从胃肠道缓慢吸收，与其他H2受体阻滞剂相比，其对胃的抑酸作用持久。围手术期胃液分泌减少被认为对患者有利，这不仅是因为它降低了误吸性肺炎的风险，还因为它降低了酸性胃内容物胃食管反流引起支气管痉挛的风险。在93例三个年龄组（Y组：20 - 40岁，M组：41 - 64岁，O组：65岁及以上）的患者中，使用两种麻醉剂（异氟烷和丙泊酚），研究了术前夜间单次口服150 mg醋酸罗沙替丁盐酸盐对麻醉期间胃液量和pH值的影响。在任何年龄组中，使用任何一种麻醉剂时，在麻醉诱导时和诱导后2小时都发现罗沙替丁对胃液分泌减少有作用。O组诱导时罗沙替丁的血清浓度更高。根据术中血清浓度测量估算口服后20小时罗沙替丁的残留浓度值。结果表明，对于年龄最大的组，术前夜间单次给药就足够了，但对于较年轻的组，建议增加剂量。
