Kojima A, Andoh K, Shima T, Koga Y, Hashimoto Y
Department of Anesthesiology, Sendai Red Cross Hospital.
Masui. 1991 Mar;40(3):451-3.
The effect of roxatidine acetate hydrochloride, administered 3 hours prior to induction of anesthesia, on pH and volume of gastric juice was investigated in preoperative patients. In fifty patients, who were scheduled to undergo elective surgery, 150 mg of roxatidine acetate hydrochloride was administered orally 3 hours before the induction of anesthesia. The volume and pH of gastric juice were measured immediately after the induction of anesthesia. In 46 patients out of fifty, pH of gastric juice was more than 2.5, and its volume was below 25 ml. In another 4 patients, pH of gastric juice was more than 2.5, or its volume below 25 ml. We conclude that, oral administration of 150 mg roxatidine 3 hours preoperatively could be effective for the prevention of an aspiration pneumonitis.
在术前患者中研究了在麻醉诱导前3小时给予醋酸罗沙替丁盐酸盐对胃液pH值和体积的影响。在50例计划接受择期手术的患者中，在麻醉诱导前3小时口服150mg醋酸罗沙替丁盐酸盐。麻醉诱导后立即测量胃液的体积和pH值。50例患者中有46例胃液pH值大于2.5，且体积低于25ml。另外4例患者，胃液pH值大于2.5或体积低于25ml。我们得出结论，术前3小时口服150mg罗沙替丁对预防误吸性肺炎可能有效。
