Poetke M, Philipp C, Berlien H P
Abteilung für Lasermedizin, Krankenhaus Neukölln, Rudower Strasse 48, 12313 Berlin.
Hautarzt. 2001 Feb;52(2):120-7. doi: 10.1007/s105-001-8038-3.
The efficacy of flashlamp-pumped pulsed dye laser therapy at 585 nm for cutaneous and mixed hemangiomas was assessed in 165 children with 225 separate hemangiomas were treated in 332 sittings over 2.5 years. The patients were divided into three groups: 100 patients with 153 flat cutaneous hemangiomas, 47 patients with 54 mixed cutaneous-subcutaneous hemangiomas and 18 patients with 18 superficial hemangiomas in the involution phase. In the first group of 100 patients with 153 flat cutaneous hemangiomas, 52 (34%) of the lesions showed total lightening. 21 of the 153 lesions showed proliferation of the subcutaneous component, although these lesions were flat at first presentation. Of the 54 mixed hemangiomas, 33 (61%) had continued proliferation of the subcutaneous component. The cutaneous component responded to therapy in 21 (39%) hemangiomas while the subcutaneous component of the mixed hemangiomas remained unchanged. No lesions in this group involuted completely and therapy was discontinued because of a relatively poor response to therapy. 12 (67%) of the 18 patients with superficial hemangiomas in the involution phase had excellent results, and 6 (33%) had good results. We conclude that treatment with the flashlamp-pumped pulsed dye laser is very effective and may be the treatment of choice for selected hemangiomas, especially cutaneous hemangiomas at sites of potential functional impairment (hands or feet, anogenital-region), and on the face. Furthermore, laser therapy should be initiated as early as possible, even in the first days or weeks of life, when the hemangioma is flat, to prevent enlargement, promote involution, or eliminate these vascular lesions.
在2.5年的时间里,对165名患有225处不同血管瘤的儿童进行了评估,以确定585nm闪光灯泵浦脉冲染料激光疗法对皮肤和混合型血管瘤的疗效。这些患者被分为三组:100名患有153处扁平皮肤血管瘤的患者,47名患有54处皮肤-皮下混合型血管瘤的患者,以及18名处于消退期的18处浅表血管瘤患者。在第一组100名患有153处扁平皮肤血管瘤的患者中,52处(34%)病变完全消退。153处病变中有21处出现皮下成分增生,尽管这些病变初发时是扁平的。在54处混合型血管瘤中,33处(61%)皮下成分持续增生。21处(39%)血管瘤的皮肤成分对治疗有反应,而混合型血管瘤的皮下成分保持不变。该组中没有病变完全消退,由于对治疗反应相对较差,治疗停止。18名处于消退期的浅表血管瘤患者中有12名(67%)效果极佳,6名(33%)效果良好。我们得出结论,闪光灯泵浦脉冲染料激光治疗非常有效,可能是某些血管瘤的首选治疗方法,尤其是潜在功能受损部位(手或脚、肛门生殖器区域)以及面部的皮肤血管瘤。此外,即使在出生后的头几天或几周,当血管瘤还处于扁平状态时,就应尽早开始激光治疗,以防止其增大,促进消退或消除这些血管病变。