Michel S, Wlotzke U, Hohenleutner U, Landthaler M
Dermatologische Klinik und Poliklinik, Universität Regensburg.
Hautarzt. 1998 Mar;49(3):192-6. doi: 10.1007/s001050050726.
In our comparative study, 40 infants ranging in age from 1 week to six months, were treated for their hemangiomas. Cryosurgery was performed on 20 hemangiomas whereas the others were treated with flash lamp-pumped pulsed dye laser (FPDL). In 72% of initial macular, flat-topped, superficial hemangiomas a predominant (> 75%) or complete regression could be achieved. In 68% of cutaneous-exophytic lesions, both therapeutical modalities showed a sufficient regression (> 50%) or marked growth inhibition after two sessions with further improvement after additional treatment. Cutaneous hemangiomas and the cutaneous part of combined hemangiomas responded well to both therapies whereas subcutaneous hemangiomas were predominantly influenced by cryotherapy. Our data emphasise the efficiency of early treatment of childhood hemangiomas. Since FPDL therapy is easy to perform, less time-consuming and reduces post-therapeutic exsudation, this treatment is preferable in initial macular, flat-topped and superficial lesions while cryotherapy is considered to be superior in lesions with marked elevated and/or subcutaneous parts.
在我们的对比研究中,对40例年龄在1周龄至6个月之间的婴儿的血管瘤进行了治疗。对其中20例血管瘤实施了冷冻手术,其余的则采用闪光灯泵浦脉冲染料激光(FPDL)治疗。在72%最初为斑状、扁平状、浅表性血管瘤的病例中,可实现显著(>75%)或完全消退。在68%的皮肤外生性病变病例中,两种治疗方式在两次治疗后均显示出足够的消退(>50%)或明显的生长抑制,在后续治疗后进一步改善。皮肤血管瘤以及混合型血管瘤的皮肤部分对两种治疗均反应良好,而皮下血管瘤主要受冷冻疗法影响。我们的数据强调了儿童血管瘤早期治疗的有效性。由于FPDL治疗操作简便、耗时较少且能减少治疗后渗出,因此对于最初为斑状、扁平状和浅表性的病变,这种治疗方法更为可取,而冷冻疗法在具有明显隆起和/或皮下部分的病变中被认为更具优势。