莫达非尼和苯丙胺对猫睡眠剥夺后睡眠-觉醒周期的影响。
Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats.
作者信息
Hou Y P, Lin J S
机构信息
Department of Anatomy, Lanzhou Medical College, Lanzhou 730000, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Sep;20(9):813-8.
AIM
The effects of modafinil and amphetamine on sleep-wake cycle and cortical power spectrum were assessed in the cats before and after sleep deprivation.
METHODS
The sleep deprivation in the cats was used with the water tank technique. Cats were administrated with modafinil (5 mg.kg-1 p.o.) or amphetamine (1 mg.kg-1) before and after sleep deprivation.
RESULTS
The waking effect of 8-10 h induced by modafinil before and after sleep deprivation was similar and was not followed by an increase in sleep rebound. On the contrary, the arousal effect about 8 h evoked by amphetamine after sleep deprivation was less lasting than that of 10-12 h observed in normal conditions and followed by an amplified rebound in both deep slow wave sleep and paradoxical sleep.
CONCLUSION
These results suggest the efficiency of modafinil against somnolence and hypersomnia without increasing subsequent sleep.
目的
评估莫达非尼和苯丙胺在睡眠剥夺前后对猫睡眠-觉醒周期及皮质功率谱的影响。
方法
采用水槽法对猫进行睡眠剥夺。在睡眠剥夺前后给猫服用莫达非尼（5毫克·千克-1，口服）或苯丙胺（1毫克·千克-1）。
结果
睡眠剥夺前后莫达非尼诱导的8 - 10小时清醒效应相似，且随后无睡眠反弹增加。相反，睡眠剥夺后苯丙胺诱发的约8小时唤醒效应不如正常情况下观察到的10 - 12小时持久，且随后慢波睡眠和异相睡眠均出现增强的反弹。
结论
这些结果表明莫达非尼对嗜睡和睡眠过多有效，且不会增加随后的睡眠。
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