Newell S M, Graham J P, Roberts G D, Ginn P E, Greiner E C, Cardwell A, Mauragis D, Knutsen C, Harrison J M, Martin F G
Department of Small Animal Clinical Sciences, University of Florida, Gainesville 32610, USA.
Vet Radiol Ultrasound. 2001 Jan-Feb;42(1):70-6. doi: 10.1111/j.1740-8261.2001.tb00906.x.
Quantitative hepatobiliary scintigraphy using 99mTc-mebrofenin was performed on eight normal cats and on the same cats after induction of experimental cholangiohepatitis by infection with the liver fluke Platynosomum concinnum. Hepatobiliary scintigraphy was performed 3 times at 10 weeks, 4 months and 6 months after infection. In addition, routine biochemical tests, hepatic ultrasound and ultrasound guided hepatic biopsy samples were obtained at the same time points, and the results compared with hepatobiliary scintigraphy. The normal hepatic extraction fraction was determined to be 85%, and the normal hepatic excretion half time (T 1/2) was 14 minutes. There was no significant change in scintigraphic parameters compared to pre-infection values at any time following infection with the liver fluke. No correlation between scintigraphic parameters and histologic scores was found; however, significant correlation was identified between parasite burden and histologic scores 6 months following infection. Despite the presence of severe multifocal histologic abnormalities, minimal clinical, biochemical and scintigraphic derangements were identified using this model of cholangiohepatitis. Based on this study, hepatobiliary scintigraphy appears to be an insensitive test for structural hepatobiliary abnormalities. The role of hepatobiliary scintigraphy in functional hepatobiliary abnormalities of the feline liver has not been determined.
对8只正常猫以及感染肝吸虫Platynosomum concinnum诱发实验性胆管肝炎后的同组猫进行了使用99mTc-美布芬宁的定量肝胆闪烁扫描。在感染后10周、4个月和6个月进行了3次肝胆闪烁扫描。此外，在相同时间点采集常规生化检测、肝脏超声和超声引导下肝活检样本，并将结果与肝胆闪烁扫描结果进行比较。正常肝脏摄取分数确定为85%，正常肝脏排泄半衰期（T 1/2）为14分钟。感染肝吸虫后的任何时间，闪烁扫描参数与感染前值相比均无显著变化。未发现闪烁扫描参数与组织学评分之间存在相关性；然而，在感染6个月后，发现寄生虫负荷与组织学评分之间存在显著相关性。尽管存在严重的多灶性组织学异常，但使用该胆管肝炎模型仅发现了轻微的临床、生化和闪烁扫描紊乱。基于本研究，肝胆闪烁扫描似乎是一种对肝胆结构异常不敏感的检测方法。尚未确定肝胆闪烁扫描在猫肝脏功能性肝胆异常中的作用。
