Syrogiannopoulos G A, Doit C, Grivea I N, Geslin P, Bingen E
Department of Pediatrics, University of Patras, School of Medicine, Greece.
Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):61-4. doi: 10.1007/pl00011236.
In January 1996 the emergence of penicillin-susceptible, multiresistant serotype 6B Streptococcus pneumoniae isolates resistant to chloramphenicol, tetracycline, erythromycin, clindamycin and trimethoprim-sulfamethoxazole was observed in young carriers in the city of Patras, located in the southwestern region of Greece. Later, a significant spread of pneumococci with this unusual phenotype was noted in carriers living in various other areas of the country. Using restriction fragment length polymorphism of the ribosomal RNA genes, clonal relationships were found between these Greek strains and serotype 6B penicillin-susceptible, multiresistant pneumococci isolated in France between January 1992 and September 1996. The French and Greek isolates appear to have a common ancestry.
1996年1月，在位于希腊西南部地区的帕特雷市的年轻带菌者中，发现了对青霉素敏感、对氯霉素、四环素、红霉素、克林霉素和甲氧苄啶-磺胺甲恶唑耐药的多重耐药6B型肺炎链球菌分离株。后来，在该国其他不同地区的带菌者中也发现了具有这种异常表型的肺炎球菌的显著传播。利用核糖体RNA基因的限制性片段长度多态性，发现这些希腊菌株与1992年1月至1996年9月间在法国分离出的6B型青霉素敏感、多重耐药肺炎球菌之间存在克隆关系。法国和希腊的分离株似乎有共同的祖先。
