Blyth M J, Kincaid R, Craigen M A, Bennet G C
Department of Orthopaedics and Trauma, Royal Hospital for Sick Children, Glasgow, Scotland, UK.
J Bone Joint Surg Br. 2001 Jan;83(1):99-102. doi: 10.1302/0301-620x.83b1.10699.
We have reviewed the incidence of bacteriologically or radiologically confirmed acute haematogenous osteomyelitis in children under 13 years of age resident in the area of the Greater Glasgow Health Board between 1990 and 1997. In this period there was a fall of 44% in the incidence of both acute and subacute osteomyelitis, mainly involving the acute form (p = 0.005). This mirrors the decline of just over 50% previously reported in the same population between 1970 and 1990. Using multiple regression analysis a decline in incidence of 0.185 cases per 100,000 population per year was calculated for the 28-year period (p < 0.001). Staphylococcus was the most commonly isolated pathogen (70%). Only 20% of patients required surgery and there was a low rate of complications (10%). In general, patients with a subacute presentation followed a benign course and there were no complications or long-term sequelae in this group. Haematogenous osteomyelitis in children in this area is becoming a rare disease with an annual incidence of 2.9 new cases per 100,000 population per year.
我们回顾了1990年至1997年间居住在大格拉斯哥健康委员会辖区内13岁以下儿童中经细菌学或放射学确诊的急性血源性骨髓炎的发病率。在此期间，急性和亚急性骨髓炎的发病率下降了44%，主要涉及急性形式（p = 0.005）。这反映了此前报道的同一人群在1970年至1990年间超过50%的下降幅度。使用多元回归分析计算出，在这28年期间，每年每10万人口的发病率下降0.185例（p < 0.001）。金黄色葡萄球菌是最常分离出的病原体（70%）。只有20%的患者需要手术，并发症发生率较低（10%）。一般来说，亚急性表现的患者病程良性，该组无并发症或长期后遗症。该地区儿童血源性骨髓炎正成为一种罕见疾病，每年每10万人口的发病率为2.9例新病例。
