Ahmad Sabeel, Barik Sitanshu, Mishra Dipun, Omar Balram Ji, Bhatia Mohit, Singh Vivek
Junior Resident, Orthopedics, All India Institute of Medical Sciences, Rishikesh, India.
Assistant Professor, Orthopedics, All India Institute of Medical Sciences, Deoghar, India.
Sudan J Paediatr. 2022;22(1):54-60. doi: 10.24911/SJP.106-1616783478.
Epidemiological data regarding paediatric pyogenic musculoskeletal infections from developing countries of Asia and Africa are sparse and further complicated by the presence of factors like malnutrition, delay in initiating treatment and belief in alternative forms of treatment and under vaccination. The aim of this study is to retrospectively analyse the cases of paediatric pyogenic musculoskeletal infections in a tertiary care centre in India.
It is a retrospective study including patients below 18 years of age who had been diagnosed with any pyogenic musculoskeletal infection. Demographic, clinical, laboratory, and radiological details were collected.
A total of 216 children, with a mean age of 12.8 ± 4.9 years (10 days-18 years), were included in the study. The causative organism could be isolated in 98 cases (45.3%). and methicillin-sensitive were the most common pathogens isolated in infants and children, respectively. Imipenem and linezolid were the commonest sensitive antibiotics for children up to 10 years and above 10 years, respectively. Linezolid was the antibiotic of choice in culture-negative cases. The majority (78.3%, = 169) of children underwent a surgical procedure during the stay at the hospital. A higher relapse rate (61%) was noted in culture-negative patients.
Improved methods of pathogen detection should be explored to improve the rate of positive cultures. Additional prospective studies with longer patient follow-up and the creation of care protocols are necessary to improve therapeutic decision-making and the prognosis for children with suspected musculoskeletal infection.
来自亚洲和非洲发展中国家的儿童化脓性肌肉骨骼感染的流行病学数据稀少，且因营养不良、治疗启动延迟、对替代治疗形式的信任以及疫苗接种不足等因素而更加复杂。本研究的目的是回顾性分析印度一家三级医疗中心的儿童化脓性肌肉骨骼感染病例。
这是一项回顾性研究，纳入了被诊断患有任何化脓性肌肉骨骼感染的18岁以下患者。收集了人口统计学、临床、实验室和放射学细节。
共有216名儿童纳入研究，平均年龄为12.8±4.9岁（10天至18岁）。98例（45.3%）可分离出致病微生物。甲氧西林敏感菌分别是婴儿和儿童中最常见的分离病原体。亚胺培南和利奈唑胺分别是10岁及以下和10岁以上儿童最常见的敏感抗生素。利奈唑胺是培养阴性病例的首选抗生素。大多数（78.3%，n=169）儿童在住院期间接受了外科手术。培养阴性患者的复发率较高（61%）。
应探索改进的病原体检测方法，以提高培养阳性率。需要进行更长时间患者随访的额外前瞻性研究并制定护理方案，以改善疑似肌肉骨骼感染儿童的治疗决策和预后。
