Malas M A, Gokcimen A, Sulak O, Candir O
Department of Anatomy, Medical Faculty, Suleyman Demirel University, 32040-Isparta, Turkey.
Early Hum Dev. 2001 Apr;62(1):65-77. doi: 10.1016/s0378-3782(01)00122-0.
The purpose of the present study is to assess the development of seminiferous tubule volume, stromal volume and total testis volume in the human fetal testis during the fetal period using the stereological method. In this study, we examined 90 testes of 45 human fetuses with no congenital anomalies and pathologies. They were aged between 12 and 40 weeks and localized between the scrotum and the abdomen. Total testis volume, seminiferous tubule volume, and stromal volume were estimated using Cavalier Principles. The weight and density of the testes were calculated as well. During the fetal period, the testes were firstly found on the right in the 27th week and on the left in the 32nd week in the scrotum. At the end of the third trimester and full term, the migration of the testes into scrotum was completed (98%). When the second trimester, third trimester and full term fetuses were compared, the differences between testis volumes were significant (p<0.001). The density of the testes between the groups was not significant (p>0.05). Testis parameters during the fetal period were not significantly (p>0.05) different between the right and left testes localization. The correlation between the fetal testis parameters was significant (p<0.001). Towards the end of the fetal period, the rate of seminiferous tubule volume to stromal volume changed in the favor of seminiferous tubule volume. It was observed that interstitial tissue became more regular and had a good organized structure with the progress of gestational age. In the third trimester, the lumen in the seminiferous tubules became more regular and clear and the interstitial tissue had a clear appearance.
本研究的目的是采用体视学方法评估人类胎儿期睾丸中曲细精管体积、间质体积和睾丸总体积的发育情况。在本研究中，我们检查了45例无先天性异常和病变的人类胎儿的90个睾丸。这些胎儿年龄在12至40周之间，位于阴囊和腹部之间。使用卡瓦列里原理估计睾丸总体积、曲细精管体积和间质体积。还计算了睾丸的重量和密度。在胎儿期，睾丸首先在第27周出现在右侧阴囊，在第32周出现在左侧阴囊。在妊娠晚期和足月时，睾丸向阴囊的迁移完成（98%）。比较妊娠中期、晚期和足月胎儿时，睾丸体积之间的差异具有显著性（p<0.001）。各组之间睾丸的密度无显著性差异（p>0.05）。胎儿期睾丸参数在睾丸位于右侧和左侧之间无显著性差异（p>0.05）。胎儿睾丸参数之间的相关性具有显著性（p<0.001）。在胎儿期末期，曲细精管体积与间质体积的比例变化有利于曲细精管体积。观察到随着胎龄进展，间质组织变得更加规则，结构组织良好。在妊娠晚期，曲细精管中的管腔变得更加规则和清晰，间质组织外观清晰。
