HMG1和HMG2以及相关的“结构”DNA结合蛋白。

HMG1 and 2, and related 'architectural' DNA-binding proteins.

作者信息

Thomas J O, Travers A A

机构信息

Cambridge Centre for Molecular Recognition, University of Cambridge, 80 Tennis Court Road, Cambridge, UK CB2 1GA.

出版信息

Trends Biochem Sci. 2001 Mar;26(3):167-74. doi: 10.1016/s0968-0004(01)01801-1.

DOI:10.1016/s0968-0004(01)01801-1

PMID:11246022

Abstract

The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins, bend DNA and bind preferentially to distorted DNA structures. The proteins appear to act primarily as architectural facilitators in the assembly of nucleoprotein complexes; for example, in effecting recombination and in the initiation of transcription. HMG-box proteins might be targeted to particular DNA sites in chromatin by either protein-protein interactions or recognition of specific DNA structures.

摘要

HMG盒蛋白是高迁移率族（HMG）染色体蛋白三类中的一类，它能使DNA弯曲并优先结合扭曲的DNA结构。这些蛋白似乎主要作为核蛋白复合物组装过程中的结构促进因子发挥作用；例如，在影响重组和转录起始方面。HMG盒蛋白可能通过蛋白质-蛋白质相互作用或对特定DNA结构的识别而靶向染色质中的特定DNA位点。