抗α- fodrin自身抗体是儿童原发性干燥综合征的早期诊断标志物。
Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome.
作者信息
Kobayashi I, Kawamura N, Okano M, Shikano T, Mizumoto M, Hayashi Y, Kobayashi K
机构信息
Department of Pediatrics, Hokkaido University School of Medicine, Pediatric Clinics, Sapporo Kohnan Hospital, Sapporo, Japan.
出版信息
J Rheumatol. 2001 Feb;28(2):363-5.
OBJECTIVE
alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS.
METHODS
We performed immunoblot analysis of sera from 7 patients with childhood primary SS using glutathione-S-transferase alpha-fodrin fusion protein as an antigen.
RESULTS
Anti-alpha-fodrin antibody was detected in sera from all 7 patients with childhood primary SS, 2 of 4 with secondary SS, and one of 7 with systemic lupus erythematosus, but in no other healthy controls.
CONCLUSION
The anti-alpha-fodrin autoantibody was detected before anti-SSA or SSB antibody became positive; thus anti-alpha-fodrin antibody could be a useful marker for the early diagnosis of SS.
目的
α- fodrin是最近发现的与成人原发性干燥综合征（SS）相关的自身抗原。我们测试了抗α- fodrin抗体是否也可作为儿童SS的诊断标志物。
方法
我们以谷胱甘肽-S-转移酶α- fodrin融合蛋白为抗原，对7例儿童原发性SS患者的血清进行免疫印迹分析。
结果
在所有7例儿童原发性SS患者、4例继发性SS患者中的2例以及7例系统性红斑狼疮患者中的1例血清中检测到抗α- fodrin抗体，但在其他健康对照中未检测到。
结论
在抗SSA或SSB抗体呈阳性之前就检测到了抗α- fodrin自身抗体；因此抗α- fodrin抗体可能是SS早期诊断的有用标志物。
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