Rudnicka L, Stachura J
Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków.
Pol J Pathol. 2000;51(3):137-43.
Morphological analysis was made in a group of 52 breast cancers, in which ductal carcinoma in situ (DCIS) was coexisted with invasive ductal carcinoma. DCIS was graded according to the cytological, Van Nuys and Holland classifications sharing a criterion of evaluating the degree of cancer cell nuclear atypia, and the histological classification. Histological grading of invasive breast carcinoma was based upon the modified Bloom and Richardson classification. Statistical analysis revealed a significant correlation between grades of invasive carcinoma and concomitant DCIS. This indicates a high prognostic value of above-mentioned DCIS classifications, proving their clinical usefulness. The Van Nuys classification should be recommended as its criteria are precise and there is no need to isolate DCIS with intermediate nuclear atypia, which improves assessment of the lesion.
对一组52例同时存在导管原位癌（DCIS）和浸润性导管癌的乳腺癌进行了形态学分析。DCIS根据细胞学、范努伊斯（Van Nuys）和霍兰德（Holland）分类法进行分级，这些分类法共享评估癌细胞核异型程度的标准以及组织学分类。浸润性乳腺癌的组织学分级基于改良的布鲁姆（Bloom）和理查森（Richardson）分类法。统计分析显示浸润性癌的分级与伴随的DCIS之间存在显著相关性。这表明上述DCIS分类具有较高的预后价值，证明了它们在临床上的实用性。推荐使用范努伊斯分类法，因为其标准精确，无需将核异型程度中等的DCIS分离出来，从而改善了对病变的评估。
