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关于人类女性发育早期X染色体失活的证据。

Evidence for the inactivation of an X chromosome early in the development of the human female.

作者信息

Migeon B R, Kennedy J F

出版信息

Am J Hum Genet. 1975 Mar;27(2):233-9.

PMID:1124767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1762755/
Abstract

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose-6-phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 weeks from conception.

摘要

对葡萄糖-6-磷酸脱氢酶电泳变体杂合的人类胚胎的体细胞组织和培养细胞（包括成纤维细胞克隆）的研究证实，一条X染色体在胚胎发育的早期就会失活，并且表明至少在受孕5周后，来自各种组织的大多数细胞中都发生了X染色体失活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/1762755/87f3b7764ed7/ajhg00435-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/1762755/87f3b7764ed7/ajhg00435-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fae/1762755/87f3b7764ed7/ajhg00435-0103-a.jpg

相似文献

1
Evidence for the inactivation of an X chromosome early in the development of the human female.关于人类女性发育早期X染色体失活的证据。
Am J Hum Genet. 1975 Mar;27(2):233-9.
2
Human phosphoglycerate kinase and inactivation of the X chromosome.
Science. 1972 Mar 3;175(4025):1002-3. doi: 10.1126/science.175.4025.1002.
3
In search of non-random X inactivation: studies of fetal membranes heterozygous for glucose-6-phosphate dehydrogenase.寻找非随机X染色体失活：对葡萄糖-6-磷酸脱氢酶杂合的胎膜的研究
Am J Hum Genet. 1979 Sep;31(5):581-5.
4
Stability of X chromosomal inactivation in human somatic cells transformed by SV-40.
Humangenetik. 1975 Sep 10;29(2):165-70. doi: 10.1007/BF00430356.
5
Differential expression of steroid sulphatase locus on active and inactive human X chromosome.类固醇硫酸酯酶基因座在人类活性和失活X染色体上的差异表达。
Nature. 1982 Oct 28;299(5886):838-40. doi: 10.1038/299838a0.
6
Glucose-6-phosphate dehydrogenase as a probe for the study of X-chromosome inactivation in hunan females.葡萄糖-6-磷酸脱氢酶作为研究人类女性X染色体失活的探针。
Isozymes Curr Top Biol Med Res. 1983;9:189-200.
7
Stability of the "two active X" phenotype in triploid somatic cells.三倍体体细胞中“两个活跃X染色体”表型的稳定性。
Cell. 1979 Nov;18(3):637-41. doi: 10.1016/0092-8674(79)90118-1.
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X chromosome inactivation in cells from an individual heterozygous for two X-linked genes.
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9
Sex differences in activity of glucose 6-phosphate dehydrogenase from cultured human fetal lung cells despite X-inactivation.
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10
Linkage relationships of X-linked enzymes glucose-6-phosphate dehydrogenase and hypoxanthine guanine phosphoribosyltransferase: recombination in female offspring of compound heterozygotes.X连锁酶葡萄糖-6-磷酸脱氢酶和次黄嘌呤鸟嘌呤磷酸核糖基转移酶的连锁关系：复合杂合子雌性后代中的重组
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Telomere-to-telomere assembly of a complete human X chromosome.端粒到端粒组装完整的人类 X 染色体。
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2
African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.在坦桑尼亚，与杂合子女性免受严重疟疾侵害相关的非洲葡萄糖-6-磷酸脱氢酶等位基因。
PLoS Genet. 2015 Feb 11;11(2):e1004960. doi: 10.1371/journal.pgen.1004960. eCollection 2015 Feb.
3
Clinical and Oculographic Findings of X-linked Congenital Nystagmus in Three Korean Families.

本文引用的文献

1
DEMONSTRATION OF TWO POPULATIONS OF CELLS IN THE HUMAN FEMALE HETEROZYGOUS FOR GLUCOSE-6-PHOSPHATE DEHYDROGENASE VARIANTS.葡萄糖-6-磷酸脱氢酶变异体杂合子的人类女性中两种细胞群体的证明。
Proc Natl Acad Sci U S A. 1963 Sep;50(3):481-5. doi: 10.1073/pnas.50.3.481.
2
Gene action in erythrocyte deficiency of glucose-6-phosphate dehydrogenase: tissue enzyme-levels.葡萄糖-6-磷酸脱氢酶红细胞缺乏症中的基因作用：组织酶水平
Nature. 1959 May 2;183(4670):1266-7. doi: 10.1038/1831266b0.
3
The occurrence of sex chromatin in early human and macaque embryos.
X 连锁先天性眼球震颤在三个韩国家族中的临床和眼动图表现。
J Clin Neurol. 2007 Sep;3(3):139-46. doi: 10.3988/jcn.2007.3.3.139. Epub 2007 Sep 20.
4
Expression of genes from the human active and inactive X chromosomes.人类活性和失活X染色体上基因的表达。
Am J Hum Genet. 1997 Jun;60(6):1333-43. doi: 10.1086/515488.
5
The postulated X-inactivation center at Xq27 is most reasonably explained by ascertainment bias: heterozygous expression of recessive mutations is a powerful means of detecting unbalanced X inactivation.位于Xq27的假定X染色体失活中心最合理的解释是确定偏倚：隐性突变的杂合表达是检测不平衡X染色体失活的有力手段。
Am J Hum Genet. 1993 Feb;52(2):431-4.
6
Phenotypic heterogeneity within clones of fetal human cells.人胎儿细胞克隆内的表型异质性。
Am J Hum Genet. 1981 Nov;33(6):950-6.
7
Fragile X syndrome: search for phenotypic manifestations at loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase.
Am J Hum Genet. 1981 Sep;33(5):752-61.
8
X chromosome reactivation in oocytes of Mus caroli.小家鼠卵母细胞中的X染色体重新激活
Proc Natl Acad Sci U S A. 1981 May;78(5):3093-7. doi: 10.1073/pnas.78.5.3093.
9
Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation.
Proc Natl Acad Sci U S A. 1980 May;77(5):2810-3. doi: 10.1073/pnas.77.5.2810.
10
In search of non-random X inactivation: studies of fetal membranes heterozygous for glucose-6-phosphate dehydrogenase.寻找非随机X染色体失活：对葡萄糖-6-磷酸脱氢酶杂合的胎膜的研究
Am J Hum Genet. 1979 Sep;31(5):581-5.
人类和猕猴早期胚胎中性染色质的出现。
J Anat. 1957 Jul;91(3):369-73.
4
Studies of skin fibroblasts from 10 families with HGPRT deficiency, with reference in X-chromosomal inactivation.对10个患有次黄嘌呤鸟嘌呤磷酸核糖转移酶（HGPRT）缺乏症的家族的皮肤成纤维细胞进行研究，并参考X染色体失活情况。
Am J Hum Genet. 1971 Mar;23(2):199-210.
5
Laboratory suggestions: a rapid method for electrophoresis of erythrocyte glucose-6-phosphate dehydrogenase on cellulose acetate plates.实验室建议：一种在醋酸纤维素板上进行红细胞葡萄糖-6-磷酸脱氢酶电泳的快速方法。
Am J Clin Pathol. 1972 Apr;57(4):534-6. doi: 10.1093/ajcp/57.4.534.
6
X chromosome inactivation studied by injection of a single cell into the mouse blastocyst.通过将单个细胞注射到小鼠囊胚中来研究X染色体失活。
Nature. 1971 Jun 11;231(5302):385-6. doi: 10.1038/231385a0.
7
Two functional X chromosomes in human fetal oocytes.
Exp Cell Res. 1973 Dec;82(2):464-6. doi: 10.1016/0014-4827(73)90368-6.
8
Sex differences in activity of glucose 6-phosphate dehydrogenase from cultured human fetal lung cells despite X-inactivation.
Biochem Genet. 1973 Jun;9(2):163-8. doi: 10.1007/BF00487445.
9
Evidence for two functional X chromosomes in human oocytes.
Cell Differ. 1972 Oct;1(4):215-8. doi: 10.1016/0045-6039(72)90039-5.
10
X-chromosome inactivation and developmental patterns in mammals.哺乳动物中的X染色体失活与发育模式。
Biol Rev Camb Philos Soc. 1972 Jan;47(1):1-35. doi: 10.1111/j.1469-185x.1972.tb00969.x.