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Chemoprevention: increased potential to bear fruit.

作者信息

Wolf C R

机构信息

Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):2941-3. doi: 10.1073/pnas.071042698.

DOI:10.1073/pnas.071042698
PMID:11248007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33333/
Abstract
摘要

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本文引用的文献

1
The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.甲基化氨基偶氮染料的代谢。V. 3-甲基胆蒽诱导大鼠酶合成的证据。
Cancer Res. 1956 Jun;16(5):450-9.
2
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.在Nrf2转录因子缺陷的小鼠中，对致癌作用的敏感性增加，酶诱导剂的化学保护功效丧失。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5. doi: 10.1073/pnas.051618798.
3
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.迈克尔反应受体作为预防癌症发生的酶诱导剂的效力取决于它们与巯基的反应活性。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3404-9. doi: 10.1073/pnas.051632198.
4
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.有说服力的证据表明，醌还原酶1型（DT黄递酶）可保护细胞免受亲电试剂和活性氧形式的毒性影响。
Free Radic Biol Med. 2000 Aug;29(3-4):231-40. doi: 10.1016/s0891-5849(00)00300-2.
5
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.Nrf2转录因子既有助于小鼠肝脏中谷胱甘肽S-转移酶的基础表达，也有助于它们被化学预防合成抗氧化剂丁基羟基茴香醚和乙氧喹啉诱导表达。
Biochem Soc Trans. 2000 Feb;28(2):33-41. doi: 10.1042/bst0280033.
6
Nrf2 is essential for protection against acute pulmonary injury in mice.Nrf2对于保护小鼠免受急性肺损伤至关重要。
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12731-6. doi: 10.1073/pnas.96.22.12731.
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Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.丝裂原活化蛋白激酶途径在化学物质诱导Ⅱ相解毒酶中的作用。
J Biol Chem. 1999 Sep 24;274(39):27545-52. doi: 10.1074/jbc.274.39.27545.
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Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress.细胞对癌症化学预防剂的反应：抗氧化反应元件对氧化和化学应激适应性反应的贡献。
Biochem Soc Symp. 1999;64:141-68.
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Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.在中国启东居民中，奥替普拉对黄曲霉毒素B1 1期和2期代谢的保护性改变。
J Natl Cancer Inst. 1999 Feb 17;91(4):347-54. doi: 10.1093/jnci/91.4.347.
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.Keap1通过与氨基末端Neh2结构域结合，抑制Nrf2对抗氧化反应元件的核激活。
Genes Dev. 1999 Jan 1;13(1):76-86. doi: 10.1101/gad.13.1.76.