Marx T, Rainov N G, Heidecke V, Burkert W
Martin-Luther-University Halle-Wittenberg, Department of Neurosurgery, Faculty of Medicine, Magdeburger Str. 16, D-06097 Halle, Germany.
Surg Neurol. 2001 Jan;55(1):41-5. doi: 10.1016/s0090-3019(00)00354-2.
There are only a few published cases of iatrogenic tumor seeding and distant neoplastic growth along the path of the cannula after stereotactic biopsy.
We report the case of a female patient with a solitary lung cancer metastasis in the left parietal brain lobe. The tumor was stereotactically biopsied and treated by radiosurgery. One month after the initial biopsy, a smaller de novo tumor mass located along the track of the stereotactic cannula was detected by contrast-enhanced MRI. The spatial location of this neoplastic nodule and the short time before development of a macroscopic lesion seemed to confirm iatrogenic tumor cell spread due to the stereotactic procedure.
Our findings and the reviewed literature suggest that this complication is rare. Nevertheless, neurosurgeons should be aware of the potential risk and, if necessary, should be able to modify the technical procedure and the adjuvant treatment.
立体定向活检后医源性肿瘤种植及沿套管路径远处肿瘤生长的已发表病例仅有少数。
我们报告一例女性患者，左顶叶脑叶有孤立性肺癌转移灶。对该肿瘤进行了立体定向活检并接受了放射外科治疗。初次活检后1个月，通过增强磁共振成像（MRI）在立体定向套管路径上检测到一个较小的新发肿瘤肿块。该肿瘤结节的空间位置以及在出现宏观病变之前的短时间似乎证实了由于立体定向操作导致的医源性肿瘤细胞播散。
我们的研究结果及综述文献表明这种并发症很罕见。然而，神经外科医生应意识到潜在风险，必要时应能够修改技术操作和辅助治疗。
