Sanno Naoko, Hayashi Shinkichi, Shimura Toshiro, Maeda Shotaro, Teramoto Akira
Department of Neurosurgery, Nippon Medical School, Tamanagayama Hospital, Tokyo, Japan.
Neurol Med Chir (Tokyo). 2004 Jan;44(1):29-32. doi: 10.2176/nmc.44.29.
A 56-year-old woman presented with an intracranial osteosarcoma at the site of previous radiosurgery, manifesting as sudden onset of headache and left hemiparesis with aphasia. She had a previous history of stereotactic radiosurgery for an intracranial tumor under a diagnosis of falx meningioma. Computed tomography showed intratumoral and peritumoral hemorrhage at the right parietofrontal region. Gross total resection of the tumor with hematoma was performed. The histological diagnosis was osteosarcoma. Sarcomatous change is a rare complication of radiotherapy. This case illustrates that osteosarcoma may develop years after radiosurgery for benign brain neoplasm.
一名56岁女性，在先前接受放射外科手术的部位出现颅内骨肉瘤，表现为突发头痛、左侧偏瘫伴失语。她既往有因诊断为镰旁脑膜瘤而接受颅内肿瘤立体定向放射外科手术的病史。计算机断层扫描显示右侧额顶叶区域肿瘤内及肿瘤周围出血。对肿瘤及血肿进行了全切除。组织学诊断为骨肉瘤。肉瘤样变是放疗的一种罕见并发症。该病例表明，骨肉瘤可能在良性脑肿瘤放射外科手术后数年发生。
