Jenab M, Chen J, Thompson L U
Department of Nutritional Sciences, University of Toronto, ON, M5S 3E2, Toronto, Canada.
Cancer Lett. 2001 Apr 10;165(1):19-25. doi: 10.1016/s0304-3835(00)00706-0.
Aberrant crypt foci (ACF) are putative early preneoplastic lesions of colon cancer. To date, many different ACF parameters have been measured as indicators of degree of colon cancer risk. It has been suggested that ACF producing sialomucins (SIM) may be more advanced types of ACF than those producing sulphomucins (SUM), but little data are available to support this. The objective of this experiment was to see if SIM ACF, as observed in whole mount colons, are different from other ACF and surrounding normal colonic crypts in terms of their rate of cell proliferation and degree of dysplasia. Results showed that all ACF had a higher rate of cell proliferation than normal crypts and that SIM ACF had higher cell proliferation in the top regions of the crypt, higher phih index of cell proliferation, higher degree of dysplasia, greater size and increased degree of luminal alterations than SUM ACF. We conclude that SIM ACF, as observed in whole mount colons, have more alterations and are more advanced towards tumorigenesis than SUM ACF and may be a better predictor of colon cancer risk than other measures of ACF.
异常隐窝灶（ACF）被认为是结肠癌的早期癌前病变。迄今为止，许多不同的ACF参数已被测量作为结肠癌风险程度的指标。有人提出，产生唾液酸粘蛋白（SIM）的ACF可能比产生硫酸粘蛋白（SUM）的ACF更高级，但几乎没有数据支持这一点。本实验的目的是观察在全层结肠中观察到的SIM ACF在细胞增殖率和发育异常程度方面是否与其他ACF以及周围正常结肠隐窝不同。结果表明，所有ACF的细胞增殖率均高于正常隐窝，并且SIM ACF在隐窝顶部区域具有更高的细胞增殖、更高的细胞增殖phih指数、更高的发育异常程度、更大的尺寸以及比SUM ACF更高的管腔改变程度。我们得出结论，在全层结肠中观察到的SIM ACF比SUM ACF有更多改变且在肿瘤发生方面更高级，并且可能比其他ACF测量方法更能预测结肠癌风险。
