Egorova A, Beltyukova S, Teslyuk O, Karpinchik V
A.V. Bogatsky Physico-chemical Institute of the National Academy of Sciences of Ukraine, 86, Lustdorfskaya doroga, 65080, Odessa, Ukraine.
J Pharm Biomed Anal. 2001 Mar;24(5-6):1081-5. doi: 10.1016/s0731-7085(00)00543-4.
A simple, rapid and sensitive luminescence method for determination of niflumic acid (NFA) is described. The method is based on the intramolecular energy transfer from niflumic acid to terbium ion (Tb(3+)) in the presence of trioctylphosphine oxide (TOPO). Optimum conditions for the formation of the NFA-Tb(3+)-TOPO ternary complex have been investigated. The calibration graph is linear over the range 0.002--0.02 microg ml(-1). The relative standard deviation is close to 4%. The recoveries obtained by applying the method to the analysis of urine ranged from 94--102%.
