用于布洛芬分子识别的铽离子发光配合物。

Luminescent complexes of terbium ion for molecular recognition of ibuprofen.

作者信息

Selivanova Natalia, Vasilieva Kristina, Galyametdinov Yury

机构信息

Kazan National Research Technological University, Department Physical and Colloid Chemistry, K. Marks 68, Kazan, 420015, Russia.

出版信息

Luminescence. 2014 May;29(3):202-10. doi: 10.1002/bio.2526. Epub 2013 May 27.

DOI:10.1002/bio.2526

PMID:23713065

Abstract

The complexation behavior and luminescent properties of terbium (Tb(3+) ) complexes containing bi-dental ligands were studied: nitrogen - 1,10-phenanthroline, and oxygen - trifluoroacetylacetone as well as acetylacetone ligands with ibuprofen (Ibu; a non-steroidal anti-inflammatory drug). Aqueous and aqueous alcohol microheterogeneous solutions were used as media. The effects of solubilization by various micellar solutions, pH and ligand type on luminescent properties of Tb(3+) complexes were investigated. Sensitized luminescence of mixed ligand complex Tb(1,10-phenanthroline)-Ibu and dynamic quenching effect in complex Tb(trifluoroacetylacetone)3 -Ibu allow Ibu determination with the limit of detection 5.3 × 10(-8) mol/L and 1.26 × 10(-6) mol/L, respectively.

摘要

研究了含有双齿配体的铽（Tb(3+)）配合物的络合行为和发光性质：含氮的1,10-菲咯啉、含氧的三氟乙酰丙酮以及乙酰丙酮配体与布洛芬（Ibu；一种非甾体抗炎药）。以水和水醇微不均匀溶液为介质。研究了各种胶束溶液的增溶作用、pH值和配体类型对Tb(3+)配合物发光性质的影响。混合配体配合物Tb(1,10-菲咯啉)-Ibu的敏化发光以及配合物Tb(三氟乙酰丙酮)3-Ibu中的动态猝灭效应分别使布洛芬的检测限达到5.3×10(-8)mol/L和1.26×10(-6)mol/L。