作为DNA损伤传感器的DNA-PK、ATM和ATR：同一主题的变体？
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
作者信息
Durocher D, Jackson S P
机构信息
Wellcome Trust and Cancer Research Campaign Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, CB2 1QR, Cambridge, UK.
出版信息
Curr Opin Cell Biol. 2001 Apr;13(2):225-31. doi: 10.1016/s0955-0674(00)00201-5.
The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.
DNA损伤信号通路是细胞对基因毒性损伤反应的核心要素，其组成部分在抵御肿瘤转化中发挥关键作用。最近的研究表明，人类的ATM和ATR蛋白及其酵母同源物密切参与了DNA损伤的感知，这表明它们与DNA双链断裂修复酶DNA-PK存在相似之处。
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