犬血友病A中冷沉淀凝血因子VIII的清除率
Clearance of cryoprecipitated factor VIII in canine hemophilia A.
作者信息
Aufderheide W M, Skinner S F, Kaneko J J
出版信息
Am J Vet Res. 1975 Apr;36(4 Pt.1):367-70.
PMID:1124873
Abstract
Canine factor VIII was isolated by a cryoprecipitation method and injected into dogs with hemophilia A. Assays of factor VIII in the cryoprecipitate resulted in a range of 92 to 660% of the factor VIII level of normal dog plasma, with a mean of 266%. Half times of the cryoprecipitate in the hemophiliac dogs, as measured by the partial thromboplastin time (PTT) test, ranged from 7.7 to 32.3 hours, with a mean of 13.2 hours.
摘要
通过冷沉淀法分离犬因子VIII，并将其注射到患有A型血友病的犬体内。对冷沉淀物中因子VIII的检测结果显示，其含量为正常犬血浆中因子VIII水平的92%至660%，平均为266%。通过部分凝血活酶时间（PTT）测试测定，血友病犬体内冷沉淀物的半衰期为7.7至32.3小时，平均为13.2小时。
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