Andreescu A C, Cushman M, Hammond J M, Wood M E
Department of Medicine, University of Vermont, Burlington 05401, USA.
J Thromb Thrombolysis. 2001 Feb;11(1):33-7. doi: 10.1023/a:1008952126124.
We report here a case of recurrent venous and arterial thromboembolism, Trousseau's syndrome, in a cancer patient who developed heparin-induced thrombocytopenia. She was treated with lepirudin and after establishing the patient-specific half-life for subcutaneous lepirudin, she was successfully maintained on this therapy for more than eight months. To our knowledge this case represents the longest reported use of subcutaneous lepirudin.
我们在此报告一例癌症患者发生复发性静脉和动脉血栓栓塞（即特鲁索综合征），该患者出现了肝素诱导的血小板减少症。她接受了比伐卢定治疗，在确定了皮下注射比伐卢定的个体半衰期后，她成功接受该治疗超过八个月。据我们所知，此病例是皮下注射比伐卢定使用时间报道最长的。
