Marrack P, Bender J, Hildeman D, Jordan M, Mitchell T, Murakami M, Sakamoto A, Schaefer B C, Swanson B, Kappler J
Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, CO 80206, USA.
Nat Immunol. 2000 Aug;1(2):107-11. doi: 10.1038/77778.
Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.
细胞因子在T细胞生存的各个阶段都有助于T细胞的稳态。然而，随着T细胞从幼稚状态发展到激活状态再到记忆状态，所涉及的特定细胞因子会有所不同。在许多情况下，重要的细胞因子是短链I型细胞因子白细胞介素2亚家族的成员。有人提出这样一种观点，即短链家族的进化分歧使得白细胞也同时发生了分歧。
