Billeaud C, Bouglé D, Sarda P, Combe N, Mazette S, Babin F, Entressangles B, Descomps B, Nouvelot A, Mendy F
Departementes de Neonatologie: Université Bordeaux II, Paris, France.
Eur J Clin Nutr. 1997 Aug;51(8):520-6. doi: 10.1038/sj.ejcn.1600436.
To investigate the effects of a milk formula supplemented with a alpha-linolenic acid (ALA) (18:2 n-6/18:3 n-3 ratio near 6/1) on plasma and red blood cell (RBC) fatty acids (FAs) in premature infants and compare with a non supplemented formula (18:2 n-6/18:3 n-3 = 22/1).
Infants of mothers who elected not to breast-feed were randomly assigned to either a high alpha linolenic formula (HLF: n = 31) group or a low alpha-linolenic formula (LLF: n = 32) control group. Infants fed human milk (HM: n = 25) were enrolled concurrently as a reference group. Anthropometric and biological measurements were made after two days (D2) and 15 d (D15) of enteral feeding and at the 37th week (W37) of postconceptual age. In HLF, the 18:3 n-3 content was 1.95% of total FAs (0.77% of total energy) and the 18:2 n-6/18:3 n-3 ratio was near 6/1. In LLF, the 18:3 n-3 content was 0.55% of total FAs (0.22% of total energy) and the 18:2 n-6/18:3 n-3 ratio was 22/1.
ALA supplementation had minimal effect on the n-6 series, did not alter the anthropometric data and confirmed the conversion of ALA into docosahexaenoic acid (DHA). Throughout the study, it maintained, the RBC membrane DHA values within the confidence interval of those obtained in the HM group. Such was not the case with LLF CONCLUSION: alpha-linolenic acid supplementation (from Rapeseed oil and in a 18:2 n-6/18:3 n-3 ratio = 6) in premature infant formula can contribute efficiently to the maintenance of the n-3 status in the premature newborns.
研究添加α-亚麻酸（ALA）（18:2 n-6/18:3 n-3比例接近6/1）的配方奶对早产儿血浆和红细胞（RBC）脂肪酸（FAs）的影响，并与未添加的配方奶（18:2 n-6/18:3 n-3 = 22/1）进行比较。
选择不进行母乳喂养的母亲所生婴儿，随机分为高α-亚麻酸配方奶组（HLF：n = 31）或低α-亚麻酸配方奶对照组（LLF：n = 32）。同时招募母乳喂养（HM：n = 25）的婴儿作为参照组。在肠内喂养2天（D2）和15天（D15）后以及孕龄37周（W37）时进行人体测量和生物学测量。在HLF中，18:3 n-3含量占总脂肪酸的1.95%（占总能量的0.77%），18:2 n-6/18:3 n-3比例接近6/1。在LLF中，18:3 n-3含量占总脂肪酸的0.55%（占总能量的0.22%），18:2 n-6/18:3 n-3比例为22/1。
补充ALA对n-6系列影响极小，未改变人体测量数据，并证实ALA可转化为二十二碳六烯酸（DHA）。在整个研究过程中，它将RBC膜DHA值维持在HM组获得的值的置信区间内。LLF组则不然。结论：早产儿配方奶中补充α-亚麻酸（来自菜籽油，18:2 n-6/18:3 n-3比例 = 6）可有效维持早产新生儿的n-3状态。
