Herz J
Department of Molecular Genetics, UT Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.
Trends Neurosci. 2001 Apr;24(4):193-5. doi: 10.1016/s0166-2236(00)01768-9.
Lipoprotein receptors were originally considered simply as cellular transporters for cholesterol and other lipids. This view is rapidly changing. Signaling functions have recently been recognized in several members of the low-density lipoprotein receptor gene family. These Apolipoprotein E receptors are highly expressed in the developing and in the mature nervous system, in which they regulate crucial developmental processes and might also participate in synaptic neurotransmission.
脂蛋白受体最初仅仅被视为胆固醇和其他脂质的细胞转运体。但这种观点正在迅速改变。最近，低密度脂蛋白受体基因家族的几个成员被发现具有信号传导功能。这些载脂蛋白E受体在发育中的和成熟的神经系统中高度表达，在其中它们调节关键的发育过程，并且可能也参与突触神经传递。
