Smirnoff P, Almiral-Seliger D, Schwartz B
Institute of Biochemistry, Food and Nutritional Sciences, The Hebrew University of Jerusalem, Rehovot, Israel.
J Nutr Health Aging. 2001;5(1):29-32.
Assessment of whether, there is a positive correlation between serum leptin levels, and BMI or/ nutritional status in the elderly as reported for the younger population.
A cross-sectional study, conducted in 62 elderly residents of a nursing home in Israel, and the subjects were divided into three different categories according to BMI. Serum leptin and other biochemical parameters were assessed. Correlation was calculated by the Pearson's correlation coefficients and statistical analysis by paired Student's t test. The relationship of BMI, leptin levels and nutritional status was determined.
Significant differences between men and women were obtained for weight, total energy intake, carbohydrates, cholesterol and leptin. Serum leptin levels in women were three times higher than in men and higher compared with to their respective parallel BMI categories in men. A positive correlated scattering between BMI and leptin levels (r=0.65, p< 0.0001) was shown only for the different BMI categories in women.
In the elderly, as in the young population, a positive correlation was obtained for BMI and leptin. In addition, significantly higher differences in circulating leptin were found in the women compared with the consistently low levels found in the men. The results suggest that female hormones do not play a significant role in determining serum leptin levels.
评估血清瘦素水平与老年人的体重指数（BMI）及营养状况之间是否如在年轻人中所报道的那样存在正相关。
对以色列一家养老院的62名老年居民进行了一项横断面研究，根据BMI将受试者分为三类。评估血清瘦素和其他生化参数。通过Pearson相关系数计算相关性，并采用配对学生t检验进行统计分析。确定BMI、瘦素水平与营养状况之间的关系。
在体重、总能量摄入、碳水化合物、胆固醇和瘦素方面，男性和女性之间存在显著差异。女性的血清瘦素水平是男性的三倍，且与男性各自相应的BMI类别相比更高。仅在女性的不同BMI类别中显示出BMI与瘦素水平之间存在正相关散点图（r = 0.65，p < 0.0001）。
在老年人中，与年轻人一样，BMI与瘦素之间存在正相关。此外，与男性持续的低水平相比，女性循环瘦素的差异显著更高。结果表明，女性激素在决定血清瘦素水平方面不起重要作用。
