中国大陆健康女性血清瘦素与年龄、体重、体重指数及骨密度的关系

Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women.

作者信息

Zhong Ni, Wu Xian-Ping, Xu Zhang-Rong, Wang Ai-Hong, Luo Xiang-Hang, Cao Xing-Zhi, Xie Hui, Shan Peng-Fei, Liao Er-Yuan

机构信息

Institute of Endocrinology and Metabolism, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, P.R. China.

出版信息

Clin Chim Acta. 2005 Jan;351(1-2):161-8. doi: 10.1016/j.cccn.2004.09.003.

DOI:10.1016/j.cccn.2004.09.003

PMID:15563886

Abstract

BACKGROUND

Serum leptin concentration is associated with age, fat and bone mineral density (BMD), and there are ethnic differences in physique and BMD values. The relationship between serum leptin concentration and BMD in Chinese women is presently unknown. We examined the relationship of serum leptin concentration with age, body weight, BMI and BMD in mainland Chinese women.

METHODS

Serum leptin concentration in a population of 676 Chinese females, aged 20-80 years (45.4+/-14.8 years, mean+/-S.D.), was measured using an enzyme-linked immunosorbent assay (ELISA). BMD values were measured by dual-energy X-ray absorptiometry (DXA) at a number of sites: the posteroanterior lumbar spine (PA, L1-L4), lateral lumbar spine (Lat, L2-L4), hip (including the femoral neck (FN) and total hip (T-hip)), and forearm (one-third region (RU1/3) and total region (RUT)). The relationship between changes in serum leptin concentration with age, body weight, height, body mass index (BMI) and BMD values at six sites were analyzed using 10 different regression models, and the models giving the best fit were selected.

RESULTS

The cubic regression model best described the changes in serum leptin concentration with age (R(2)=0.048, p<0.001) and body weight (R(2)=0.352, p<0.001), while the quadratic regression model was best for serum leptin concentration changes with BMI (R(2)=0.410, p<0.001); serum leptin concentration was not correlated with height. Serum leptin concentration was significantly higher in postmenopausal than premenopausal women (p<0.001). Serum leptin concentration was correlated with Lat BMD (R(2)=0.012, p<0.018), FN BMD (R(2)=0.006, p<0.041) and T-hip BMD (R(2)=0.013, p<0.004) in the whole population. In premenopausal women, leptin was positively associated with BMD except for Lat (R(2)=0.029-0.055, p<0.008); in postmenopausal women, leptin was also positively associated with AP, FN, T-hip BMD (R(2)=0.026-0.042, p<0.007). However, after adjusting for BMI not for body weight, there was no association between serum leptin concentration and age. Meanwhile, after adjustment for age, body weight and BMI, there was no association between serum leptin concentration and BMD values in premenopausal and postmenopausal women.

CONCLUSIONS

Age-related changes in serum leptin concentration is dependent on BMI, but not a direct determinant of BMD in Chinese females.

摘要

背景

血清瘦素浓度与年龄、脂肪及骨密度（BMD）相关，且在体格和骨密度值方面存在种族差异。目前尚不清楚中国女性血清瘦素浓度与骨密度之间的关系。我们研究了中国大陆女性血清瘦素浓度与年龄、体重、体重指数（BMI）及骨密度之间的关系。

方法

采用酶联免疫吸附测定法（ELISA）测量了676名年龄在20 - 80岁（平均45.4±14.8岁，均值±标准差）中国女性的血清瘦素浓度。通过双能X线吸收法（DXA）在多个部位测量骨密度值：腰椎前后位（PA，L1 - L4）、腰椎侧位（Lat，L2 - L4）、髋部（包括股骨颈（FN）和全髋（T-hip））以及前臂（三分之一区域（RU1/3）和全区域（RUT））。使用10种不同的回归模型分析血清瘦素浓度变化与年龄、体重、身高、体重指数（BMI）及六个部位骨密度值之间的关系，并选择拟合度最佳的模型。

结果

三次回归模型最能描述血清瘦素浓度随年龄（R² = 0.048，p < 0.001）和体重（R² = 0.352，p < 0.001）的变化，而二次回归模型最适合血清瘦素浓度随BMI的变化（R² = 0.410，p < 0.001）；血清瘦素浓度与身高无关。绝经后女性的血清瘦素浓度显著高于绝经前女性（p < 0.001）。在总体人群中，血清瘦素浓度与腰椎侧位骨密度（R² = 0.012，p < 0.018）、股骨颈骨密度（R² = 0.006，p < 0.041）和全髋骨密度（R² = 0.013，p < 0.004）相关。在绝经前女性中，除腰椎侧位外，瘦素与骨密度呈正相关（R² = 0.029 - 0.055，p < 0.008）；在绝经后女性中，瘦素也与腰椎前后位、股骨颈、全髋骨密度呈正相关（R² = 0.026 - 0.042，p < 0.007）。然而，在调整BMI而非体重后，血清瘦素浓度与年龄之间无关联。同时，在调整年龄、体重和BMI后，绝经前和绝经后女性的血清瘦素浓度与骨密度值之间无关联。