Zhang X, Yee D
University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA.
Breast Cancer Res. 2000;2(3):170-5. doi: 10.1186/bcr50. Epub 2000 Mar 6.
The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
胰岛素样生长因子(IGF)系统对哺乳动物细胞具有多效性作用。本综述聚焦于I型IGF受体(IGF1R)介导的信号转导及其在乳腺癌中的相关性。在被IGF激活后,IGF1R(一种跨膜酪氨酸激酶受体)发生自磷酸化,然后结合并磷酸化其他信号分子。这些中间体引发一系列下游信号事件,这些事件参与细胞的多种生理过程。最近的数据表明,IGF受体系统与雌激素受体和整合素受体系统积极相互作用。这些途径之间的相互作用调节乳腺癌的增殖、细胞死亡保护和转移。更好地理解IGF生化信号通路对于开发乳腺癌治疗方法至关重要。