乳腺癌中的酪氨酸激酶信号传导：乳腺癌中的胰岛素样生长因子及其受体
Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.
作者信息
Zhang X, Yee D
机构信息
University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA.
出版信息
Breast Cancer Res. 2000;2(3):170-5. doi: 10.1186/bcr50. Epub 2000 Mar 6.
Abstract
The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
摘要
胰岛素样生长因子（IGF）系统对哺乳动物细胞具有多效性作用。本综述聚焦于I型IGF受体（IGF1R）介导的信号转导及其在乳腺癌中的相关性。在被IGF激活后，IGF1R（一种跨膜酪氨酸激酶受体）发生自磷酸化，然后结合并磷酸化其他信号分子。这些中间体引发一系列下游信号事件，这些事件参与细胞的多种生理过程。最近的数据表明，IGF受体系统与雌激素受体和整合素受体系统积极相互作用。这些途径之间的相互作用调节乳腺癌的增殖、细胞死亡保护和转移。更好地理解IGF生化信号通路对于开发乳腺癌治疗方法至关重要。
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本文引用的文献
1
Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation.
J Biol Chem. 1999 Oct 29;274(44):31179-84. doi: 10.1074/jbc.274.44.31179.
2
Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects.胰岛素样生长因子（IGF）-I可使乳腺癌细胞免受化疗诱导的细胞死亡——具有增殖和抗凋亡作用。
Breast Cancer Res Treat. 1999 Jul;56(1):1-10. doi: 10.1023/a:1006208721167.
3
Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.癌症相关错义突变对配体与胰岛素样生长因子II/甘露糖6-磷酸受体结合的破坏作用。
J Biol Chem. 1999 Aug 20;274(34):24408-16. doi: 10.1074/jbc.274.34.24408.
4
The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.活化的胰岛素样生长因子I受体可诱导乳腺上皮细胞发生去极化，其特征为肌动蛋白丝解聚以及粘着斑激酶、Cas和桩蛋白的酪氨酸去磷酸化。
Exp Cell Res. 1999 Aug 25;251(1):244-55. doi: 10.1006/excr.1999.4566.
5
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.乳腺癌中胰岛素及胰岛素样生长因子-I（IGF-I）受体的过表达导致胰岛素/IGF-I杂合受体的过表达：IGF-I信号传导第二种机制的证据。
Clin Cancer Res. 1999 Jul;5(7):1935-44.
6
Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells.AKT1在17β-雌二醇和胰岛素样生长因子I（IGF-I）依赖性MCF-7乳腺癌细胞增殖及凋亡预防中的作用。
Biochem Pharmacol. 1999 Aug 1;58(3):425-30. doi: 10.1016/s0006-2952(99)00125-2.
7
Insulin-like growth factor binding proteins: new proteins, new functions.胰岛素样生长因子结合蛋白：新蛋白，新功能。
Horm Res. 1999;51(2):53-67. doi: 10.1159/000023315.
8
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Mol Endocrinol. 1999 May;13(5):787-96. doi: 10.1210/mend.13.5.0274.
9
Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism.胰岛素样生长因子-II（IGF-II）在乳腺癌中激活胰岛素受体：一种新的自分泌/旁分泌机制的证据。
Oncogene. 1999 Apr 15;18(15):2471-9. doi: 10.1038/sj.onc.1202600.
10
Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cells.胰岛素受体底物1是乳腺癌细胞中纯抗雌激素ICI 182,780的作用靶点。
Int J Cancer. 1999 Apr 12;81(2):299-304. doi: 10.1002/(SICI)1097-0215(19990412)81:2<299::AID-IJC21>3.0.CO;2-8.
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