原发性乳腺癌前哨淋巴结微转移的病理验证及意义
Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer.
作者信息
Rampaul R S, Miremadi A, Pinder S E, Lee A, Ellis I O
机构信息
Department of Pathology, Nottingham City Hospital, Nottingham, UK.
出版信息
Breast Cancer Res. 2001;3(2):113-6. doi: 10.1186/bcr282. Epub 2001 Jan 23.
Abstract
In embracing a multidisciplinary approach to the management of patients with sentinel node biopsy in breast cancer, the pathologist task is to screen sentinel nodes for possible metastasis. The consequences of missing sentinel node micrometastasis can directly influence treatment strategies, and this screening therefore has to be performed with more attention than usual. There is presently great diversity in the histopathological work-up of sentinel nodes, with many centres employing additional techniques such as immunohistochemistry, reverse transcription polymerase chain reaction or flow cytometry in addition to routine haematoxylin and eosin staining. In this review, we address the pathological validation and significance of micrometastasis in sentinel node biopsy in primary breast cancer.
摘要
在采用多学科方法管理乳腺癌前哨淋巴结活检患者时，病理学家的任务是筛查前哨淋巴结是否可能发生转移。遗漏前哨淋巴结微转移的后果会直接影响治疗策略，因此这种筛查必须比平时更加仔细。目前，前哨淋巴结的组织病理学检查方法存在很大差异，许多中心除了常规苏木精和伊红染色外，还采用免疫组织化学、逆转录聚合酶链反应或流式细胞术等额外技术。在本综述中，我们探讨了原发性乳腺癌前哨淋巴结活检中微转移的病理验证及其意义。
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